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Sean J. Johnson
Researcher at Utah State University
Publications - 33
Citations - 1380
Sean J. Johnson is an academic researcher from Utah State University. The author has contributed to research in topics: RNA & RNA Helicase A. The author has an hindex of 17, co-authored 31 publications receiving 1212 citations. Previous affiliations of Sean J. Johnson include Brookhaven National Laboratory & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
Structures of Mismatch Replication Errors Observed in a DNA Polymerase
Sean J. Johnson,Lorena S. Beese +1 more
TL;DR: A structural characterization of all 12 possible mismatches captured at the growing primer terminus in the active site of a polymerase is presented, suggesting the structural basis for the short-term memory of replication errors.
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Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations
TL;DR: The ability to observe processive, high-fidelity replication directly in a crystal of the thermostable Bacillus DNA polymerase I establishes this polymerase as a powerful model system for mechanistic studies in which the structural consequences of mismatches and DNA adducts are observed.
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Insights into the reaction of protein-tyrosine phosphatase 1B: crystal structures for transition state analogs of both catalytic steps.
TL;DR: Crystal structures for the transition state analogs for both catalytic steps of protein-tyrosine phosphatase 1B and apo-PTP1B are solved and detailed interactions between the flanking peptide and the enzyme are discussed.
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The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing.
Ryan N. Jackson,A. Alejandra Klauer,Bradley J. Hintze,Howard Robinson,Ambro van Hoof,Sean J. Johnson +5 more
TL;DR: In vivo and in vitro analyses demonstrate that the Mtr4 arch domain is required for proper 5.8S rRNA processing, and suggest that the arch functions independently of canonical helicase activity.
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Ski2-like RNA helicase structures: Common themes and complex assemblies
Sean J. Johnson,Ryan N. Jackson +1 more
TL;DR: The central role of Mtr4 and Ski2 in formation of complexes that activate RNA decay by the eukaryotic exosome is described and a role for the winged helix domain as a molecular hub that coordinates RNA interacting events throughout the helicase is suggested.