Showing papers by "Sean P. Gorman published in 2009"
TL;DR: The antibiofilm activity of a series of 1-alkyl-3-methylimidazolium chloride ionic liquids has been evaluated against a panel of clinically significant microbial pathogens, including MRSA.
244 citations
TL;DR: The ability to concentrate the photocytotoxic effect at a surface, together with a significant dark effect, provides a platform for a range of light-activated anti-infective biomaterial technologies.
75 citations
TL;DR: It is shown that MAD2 down-regulation induces premature senescence in the MCF7 breast epithelial cancer cell line and compromised MAD2 levels induce a population of senescent cells resistant to paclitaxel.
Abstract: Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro
46 citations
TL;DR: Understanding how PEG affects the release of triclosan from silicone elastomers may prove useful in the development of a biomaterial providing prolonged, effective antimicrobial activity.
41 citations
TL;DR: The development, characterisation and microbiological testing of surface‐modified polyvinylchloride (PVC) films for the purpose of reducing bacterial adherence are reported.
Abstract: Objectives This study reports the development, characterisation and microbiological testing of surface-modified polyvinylchloride (PVC) films for the purpose of reducing bacterial adherence Methods Irreversible covalent surface modification was achieved via nucleophilic substitution of fluorinated thiol-terminated compounds onto the polymer backbone Four fluorinated modifiers, 2,3,5,6-tetrafluorothiophenol (TFTP), 4-(trifluoromethyl)thiophenol (TFMTP), 3,5-bis(trifluoromethyl)benzenethiol (BTFMBT) and 3,3,4,4,5,5,6,6,7, 7,8,8,9,9,10,10,10-heptadecafluoro-decane-1-thiol (HDFDT), were investigated Modification was confirmed using attenuated total reflectance infrared spectroscopy; Raman mapping demonstrated that modification was homogenous on the macroscopic scale The influence of fluorination on surface hydrophobicity was studied by contact angle analysis The effect on microbial adherence was examined using Pseudomonas aeruginosa and Staphylococcus aureus Key findings The resultant changes in contact angle relative to control PVC ranged from -4 degrees to +14 degrees In all cases, adherence of P aeruginosa and S aureus was significantly reduced relative to control PVC, with adherence levels ranging from 62% and 51% for TFTP-modified PVC to 32% and 7% for TFMTP-modified PVC Conclusions These results demonstrate an important method in reducing the incidence of bacterial infection in PVC medical devices without compromising mechanical properties
12 citations
TL;DR: The kassinatuerin-2 related peptides of K. maculata skin secretion thus possess a discrete antimicrobial and weak haemolytic activity in contrast to the prototype k Assassinatuer in-2 from the skin secretion of Kassina senegalensis.
9 citations
Patent•
28 May 2009TL;DR: In this paper, a non-water soluble drug delivery composition comprising a conjugate and a polymer matrix was provided, where exposure of the composition to electromagnetic radiation at a suitable pre-determined wavelength and intensity induces release of the active ingredient from the composition.
Abstract: There is provided a non-water soluble drug delivery composition comprising a conjugate and a polymer matrix wherein exposure of the composition to electromagnetic radiation at a suitable pre-determined wavelength and intensity induces release of the active ingredient from the composition. The conjugate is attached to the polymer matrix through non-covalent interactions. There is also provided a drug delivery apparatus formed from the drug delivery composition.
6 citations
01 Jan 2009
TL;DR: This chapter examines the in vitro encrustation models available for evaluation and preliminary assessment of new biomaterials, coatings and drug-eluting devices for use in the urinary tract, aimed at resisting surface Encrustation and microbial biofilm formation.
Abstract: Medical devices of the urinary tract are in commonplace usage in modern urology and are likely to remain the cornerstone of many surgical interventions in the field. This is despite the fact that their effective use is still drastically hindered by the formation of biofilm and encrustation which can cause obstruction and blockage of the device, as well as significant morbidity in the patient. This chapter examines the in vitro encrustation models available for evaluation and preliminary assessment of new biomaterials, coatings and drug-eluting devices for use in the urinary tract, aimed at resisting surface encrustation and microbial biofilm formation.
5 citations
01 Oct 2009
1 citations
01 Jan 2009
TL;DR: The chapter first considers the basis of silicone chemistry for elastomer production, leading to a description of the chemistry of novel, self-lubricating silicone biomaterials, and the characteristics of these novel materials are described with respect to lubricity, mechanical performance and biocompatibility aspects.
Abstract: This chapter discusses the problem of lack of lubricity in common biomaterials, notably silicone elastomers, used in the production of urinary catheters. The chapter first considers the basis of silicone chemistry for elastomer production, leading to a description of the chemistry of novel, self-lubricating silicone biomaterials. Finally, the characteristics of these novel materials are described with respect to lubricity, mechanical performance and biocompatibility aspects.