Institution
Mater Misericordiae Hospital
Healthcare•Townsville, Queensland, Australia•
About: Mater Misericordiae Hospital is a healthcare organization based out in Townsville, Queensland, Australia. It is known for research contribution in the topics: Population & Cancer. The organization has 2366 authors who have published 2094 publications receiving 69051 citations. The organization is also known as: The Mater & Mater Hospital Pimlico.
Topics: Population, Cancer, Prostate cancer, Poison control, Pregnancy
Papers published on a yearly basis
Papers
More filters
••
Mayo Clinic1, Washington University in St. Louis2, Erasmus University Rotterdam3, Karolinska Institutet4, Albert Einstein College of Medicine5, University of Pennsylvania6, Columbia University7, Mater Misericordiae Hospital8, University of Queensland9, QIMR Berghofer Medical Research Institute10, Garvan Institute of Medical Research11, Manchester Royal Infirmary12, University of Manchester13
TL;DR: In this paper, the authors sequenced tau in FTDP-17 families and identified three missense mutations (G272V, P301L and R406W) and three mutations in the 5' splice site of exon in
Abstract: Thirteen families have been described with an autosomal dominantly inherited dementia named frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)(1-9), historically termed Pick's disease(10) Most FTDP-17 cases show neuronal and/or glial inclusions that stain positively with antibodies raised against the microtubule-associated protein Tau, although the Tau pathology varies considerably in both its quantity (or severity) and characteristics(1-8,12) Previous studies have mapped the FTDP-17 locus to a 2-centimorgan region on chromosome 17q2111; the tau gene also lies within this region We have now sequenced tau in FTDP-17 families and identified three missense mutations (G272V, P301L and R406W) and three mutations in the 5' splice site of exon in The splice-site mutations all destabilize a potential stem-loop structure which is probably involved in regulating the alternative splicing of exon10 (ref 13) This causes more frequent usage of the 5' splice site and an increased proportion of tan transcripts that include exon 10 The increase in exon 10(+) messenger RNA will increase the proportion of Tau containing four microtubule-binding repeats, which is consistent with the neuropathology described in several families with FTDP-17 (refs 12, 14)
3,366 citations
••
TL;DR: This document update and summarize new information obtained from this research and incorporate, where appropriate, the results into the BOS criteria.
Abstract: Bronchiolitis obliterans (BO) is a major cause of allograft dysfunction in lung and heart lung transplant recipients. Clinically, progressive airflow limitation develops because of small airway obstruction. The disease has a variable course. Some patients experience rapid loss of lung function and respiratory failure. Others experience either slow progression or intermittent loss of function with long plateaus during which pulmonary function is stable. Histologic confirmation is difficult because transbronchial biopsy specimens often are not sufficiently sensitive for diagnosis. Because BO is difficult to document histologically, in 1993 a committee sponsored by the International Society for Heart and Lung Transplantation (ISHLT) proposed a clinical description of BO, termed bronchiolitis obliterans syndrome (BOS) and defined by pulmonary function changes rather than histology. Although this system does not require histologic diagnosis, it does recognize it. Transplant centers worldwide have adopted the BOS system as a descriptor of lung allograft dysfunction. This allows centers to use a common language to compare program results. In the years since publication of the BOS system, transplant scientists have studied basic and clinical aspects of lung transplant BO. In this document, we update and summarize new information obtained from this research and incorporate, where appropriate, the results into the BOS criteria. The document will include the following topics: (1) criteria for BOS, (2) BOS considerations in pediatric patients, (3) risk factors for BOS, (4) pathology of BO, (5) surrogate markers for BOS, (6) confounding factors in making a BOS diagnosis, and (7) assessment of response to treatment of BOS.
1,228 citations
••
TL;DR: Pulmonary arterial hypertension is diagnosed by various investigations that are essential for making the diagnosis, and by additional tests to clarify the category of pulmonary hypertension (PH).
978 citations
••
TL;DR: During 2002 the International Association of Pancreatology developed evidenced-based guidelines on the surgical management of acute pancreatitis, which should form the basis for audit studies in order to determine the quality of patient care delivery.
718 citations
••
TL;DR: In this article, the levels of production of interleukin-6 (IL-6), IL-8, and prostaglandin E2 (PGE2) were found in disc tissue from patients undergoing discectomy for sciatica (63) with patients undergoing fusion for discogenic low back pain (20) using an enzyme-linked immunoabsorbent assay.
Abstract: Herniated intervertebral disc tissue has been shown to produce a number of proinflammatory mediators and cytokines, but there have been no similar studies using discs from patients with discogenic low back pain. We have compared the levels of production of interleukin-6 (IL-6), interleukin-8 (IL-8) and prostaglandin E2 (PGE2) in disc tissue from patients undergoing discectomy for sciatica (63) with that from patients undergoing fusion for discogenic low back pain (20) using an enzyme-linked immunoabsorbent assay. There was a statistically significant difference between levels of production of IL-6 and IL-8 in the sciatica and low back pain groups (p < 0.006 and p < 0.003, respectively). The high levels of proinflammatory mediator found in disc tissue from patients undergoing fusion suggest that production of proinflammatory mediators within the nucleus pulposus may be a major factor in the genesis of a painful lumbar disc.
636 citations
Authors
Showing all 2370 results
Name | H-index | Papers | Citations |
---|---|---|---|
James A. Russell | 124 | 1024 | 87929 |
Fergus Shanahan | 117 | 705 | 51963 |
Nikolai Bogduk | 101 | 363 | 31503 |
Gail M. Williams | 94 | 737 | 36115 |
John V. Reynolds | 92 | 797 | 41654 |
Lark L. Coffey | 92 | 342 | 25138 |
Peter Hersey | 90 | 399 | 37026 |
Robert A. Rizza | 90 | 344 | 30884 |
David Henry | 89 | 547 | 45563 |
John F. Forbes | 88 | 368 | 46433 |
Kylie Ball | 84 | 395 | 24144 |
Michael J. O'Brien | 82 | 550 | 31320 |
Pieter E. Postmus | 81 | 384 | 24039 |
Helmut G. Rennke | 77 | 256 | 33959 |
William G. Powderly | 77 | 313 | 24857 |