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Sean R. Eddy
Researcher at Harvard University
Publications - 160
Citations - 137345
Sean R. Eddy is an academic researcher from Harvard University. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 88, co-authored 156 publications receiving 123826 citations. Previous affiliations of Sean R. Eddy include Washington University in St. Louis & California Institute of Technology.
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Journal ArticleDOI
Kissing complex RNAs mediate interaction between the Fragile-X mental retardation protein KH2 domain and brain polyribosomes
Jennifer C. Darnell,Claire E. Fraser,Olga Mostovetsky,Giovanni Stefani,Thomas A. Jones,Sean R. Eddy,Robert B. Darnell +6 more
TL;DR: It is concluded that mental retardation associated with the I304N mutation, and likely the Fragile-X syndrome more generally, may relate to a crucial role for RNAs harboring the kissing complex motif as targets for FMRP translational regulation.
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ATV: display and manipulation of annotated phylogenetic trees
Christian M. Zmasek,Sean R. Eddy +1 more
TL;DR: A Tree Viewer is a Java tool for the display and manipulation of annotated phylogenetic trees that can be utilized both as a standalone application and as an applet in a web browser.
Journal ArticleDOI
Where did the BLOSUM62 alignment score matrix come from
TL;DR: Many sequence alignment programs use the BLOSUM62 score matrix to score pairs of aligned residues, but where did BLOSum62 come from?
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Evaluation of several lightweight stochastic context-free grammars for RNA secondary structure prediction.
Robin D. Dowell,Sean R. Eddy +1 more
TL;DR: Four SCFG designs had prediction accuracies near the performance of current energy minimization programs, and one of these designs, introduced by Knudsen and Hein in their PFOLD algorithm, has only 21 free parameters and is significantly simpler than the others.
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A statistical test for conserved RNA structure shows lack of evidence for structure in lncRNAs
TL;DR: R-scape analysis finds no statistically significant support for proposed secondary structures of the long noncoding RNAs HOTAIR, SRA, and Xist.