R
Robin D. Dowell
Researcher at University of Colorado Boulder
Publications - 114
Citations - 5201
Robin D. Dowell is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Gene & Chromatin. The author has an hindex of 26, co-authored 98 publications receiving 4261 citations. Previous affiliations of Robin D. Dowell include Washington University in St. Louis & University of Colorado Denver.
Papers
More filters
Journal ArticleDOI
Tissue-specific transcriptional regulation has diverged significantly between human and mouse.
Duncan T. Odom,Robin D. Dowell,Elizabeth S Jacobsen,William Gordon,Timothy Danford,Kenzie D MacIsaac,P. Alexander Rolfe,Caitlin M. Conboy,David K. Gifford,Ernest Fraenkel +9 more
TL;DR: It is demonstrated that the binding sites for highly conserved transcription factors vary extensively between human and mouse, and from 41% to 89% of their binding events seem to be species specific.
Journal ArticleDOI
The Distributed Annotation System
TL;DR: The Distributed Annotation System (DAS) allows sequence annotations to be decentralized among multiple third-party annotators and integrated on an as-needed basis by client-side software.
Journal ArticleDOI
Genotype to phenotype: a complex problem.
Robin D. Dowell,Owen Ryan,An Jansen,Doris Cheung,Sudeep D. Agarwala,Timothy Danford,Douglas A. Bernstein,P. Alexander Rolfe,Lawrence E. Heisler,Brian L. Chin,Corey Nislow,Guri Giaever,Patrick C. Phillips,Gerald R. Fink,Gerald R. Fink,David K. Gifford,David K. Gifford,Charles Boone +17 more
TL;DR: A genome-wide comparison of deletion mutant phenotypes identified a subset of genes that were conditionally essential by strain, including 44 essential genes unique to Σ1278b and 13 unique to reference strain S288c.
Journal ArticleDOI
Polyploidy can drive rapid adaptation in yeast
Anna Selmecki,Yosef E. Maruvka,Phillip A. Richmond,Marie Guillet,Marie Guillet,Noam Shoresh,Amber L. Sorenson,Subhajyoti De,Roy Kishony,Franziska Michor,Robin D. Dowell,David Pellman +11 more
TL;DR: Results provide direct quantitative evidence that in some environments polyploidy can accelerate evolutionary adaptation, and identify several mutations whose beneficial effects are manifest specifically in the tetraploid strains.
Journal ArticleDOI
HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia
Matthew D. Galbraith,Mary A. Allen,Claire L. Bensard,Xiaoxing Wang,Xiaoxing Wang,Marie K. Schwinn,Bo Qin,Bo Qin,Henry W. Long,Danette L. Daniels,William C. Hahn,William C. Hahn,Robin D. Dowell,Joaquín M. Espinosa +13 more
TL;DR: The results provide a mechanistic link between HIF1A and CDK8, two potent oncogenes, in the cellular response to hypoxia, and employ a specific variant of the Mediator complex to stimulate RNAPII elongation.