S
Sebastien Andre Campos
Researcher at GlaxoSmithKline
Publications - 42
Citations - 1583
Sebastien Andre Campos is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Ubiquitin ligase & Kinase. The author has an hindex of 18, co-authored 39 publications receiving 1231 citations. Previous affiliations of Sebastien Andre Campos include University College London & University of Hertfordshire.
Papers
More filters
Journal ArticleDOI
Catalytic in vivo protein knockdown by small-molecule PROTACs
Daniel P. Bondeson,Alina Mares,Ian Edward David Smith,Ko Eunhwa,Sebastien Andre Campos,Afjal Hussain Miah,Katie E Mulholland,Natasha Routly,Dennis L. Buckley,Jeffrey L. Gustafson,Nico Zinn,Paola Grandi,Satoko Shimamura,Giovanna Bergamini,Maria Faelth-Savitski,Marcus Bantscheff,Carly S. Cox,Deborah A. Gordon,Ryan R. Willard,John J. Flanagan,Linda N. Casillas,Bartholomew J. Votta,Willem den Besten,Kristoffer Famm,Laurens Kruidenier,Paul S. Carter,John D. Harling,Ian Churcher,Craig M. Crews +28 more
TL;DR: Major improvements to the proteolysis targeting chimeras (PROTACs) method are described, a chemical knockdown strategy in which a heterobifunctional molecule recruits a specific protein target to an E3 ubiquitin ligase, resulting in the target's ubiquitination and degradation.
Patent
Compounds&methods for the enhanced degradation of targeted proteins&other polypeptides by an e3 ubiquitin ligase
Craig M. Crews,Dennis Buckley,Alessio Ciulli,William L. Jorgensen,Peter C. Gareiss,Inge Van Molle,Jeffrey L. Gustafson,Hyun-Seop Tae,Julien Michel,Dentin Wade Hoyer,Anke G. Roth,John D. Harling,Ian Edward David Smith,Afjal Hussain Miah,Sebastien Andre Campos,Joelle Le +15 more
TL;DR: In this paper, a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides, are described.
Journal ArticleDOI
Spectroscopic studies of Yb3+-doped rare earth orthosilicate crystals
TL;DR: In this paper, the energy levels of the Yb3+ ion 2F5/2 manifold were analyzed in the same C2h6 crystallographic space group and it was shown that Yb 3+ ions experience high crystal field strength, particularly in Yb:SSO.
Journal ArticleDOI
Selectively targeting the kinome-conserved lysine of PI3Kδ as a general approach to covalent kinase inhibition
Samuel E. Dalton,Samuel E. Dalton,Lars Dittus,Daniel Thomas,Máire A. Convery,João Osvaldo Rodrigues Nunes,Jacob T. Bush,John P. Evans,Thilo Werner,Marcus Bantscheff,John A. Murphy,Sebastien Andre Campos +11 more
TL;DR: A novel approach to achieve selective, irreversible kinase inhibition, by targeting the conserved catalytic lysine residue, by developing selective, covalent PI3Kδ inhibitors that exhibit nanomolar potency in cellular assays, and a duration of action >48 h in CD4+ T cells.
Journal ArticleDOI
Site-selective deuteration of N-heterocycles via iridium-catalyzed hydrogen isotope exchange
William J. Kerr,David M. Lindsay,Philippa Kate Owens,Marc Reid,Tell Tuttle,Sebastien Andre Campos +5 more
TL;DR: The application of iridium(I) NHC/phosphine catalysts has delivered highly selective deuteration of indole, azaindole, and pyrrole N-heterocycles, which represent an important and relatively underexplored class of labeling substrates.