S
Sébastien Gaumer
Researcher at Université Paris-Saclay
Publications - 21
Citations - 1087
Sébastien Gaumer is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Programmed cell death & Protein aggregation. The author has an hindex of 12, co-authored 21 publications receiving 969 citations. Previous affiliations of Sébastien Gaumer include Versailles Saint-Quentin-en-Yvelines University & Centre national de la recherche scientifique.
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Journal ArticleDOI
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain.
Ioannis P. Nezis,Anne Simonsen,Antonia P. Sagona,Kim D. Finley,Sébastien Gaumer,D. Contamine,Tor Erik Rusten,Harald Stenmark,Andreas Brech +8 more
TL;DR: It is demonstrated that Ref(2)P localizes to age-induced protein aggregates as well as to aggregates caused by reduced autophagic or proteasomal activity, and a major role is revealed in the formation of ubiquitin-positive protein aggregation both under physiological conditions and when normal protein turnover is inhibited.
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An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
Annett Boeddrich,Sébastien Gaumer,Annette Haacke,Nikolay Tzvetkov,Mario Albrecht,Bernd O. Evert,Eva Christina Müller,Rudi Lurz,Peter Breuer,Nancy Schugardt,Stephanie Plaßmann,Kexiang Xu,John M. Warrick,Jaana Suopanki,Ullrich Wüllner,Ronald Frank,Ulrich F. Hartl,Nancy M. Bonini,Erich E. Wanker +18 more
TL;DR: The VCP–Atx‐3 association is defined as a potential target for therapeutic intervention and it is suggested that it might influence the progression of spinocerebellar ataxia type 3.
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Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila.
TL;DR: Results indicate that factors necessary for the activity of bcl-2 and bax are present in Drosophila, and may exist in the fly, and a Bcl-1 anti-apoptotic pathway for inhibition of cell death may exist.
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Bcl-2 and Hsp27 act at different levels to suppress programmed cell death
TL;DR: Comparing the protective effect of oncoprotein Bcl-2 and of the small stress protein Hsp27 on apoptosis and necrosis in rat embryo fibroblasts suggests that their protective functions only partially overlap.
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The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates.
Karine Lindmo,Andreas Brech,Kim D. Finley,Sébastien Gaumer,D. Contamine,Tor Erik Rusten,Harald Stenmark +6 more
TL;DR: These results provide the first genetic evidence for a function of Vps15 in autophagy in multicellular organisms and suggest that the Vps 15-containing PI 3-kinase complex may play an important role in clearance of protein aggregates.