M
Mario Albrecht
Researcher at Max Planck Society
Publications - 105
Citations - 13809
Mario Albrecht is an academic researcher from Max Planck Society. The author has contributed to research in topics: Protein structure & Gene. The author has an hindex of 52, co-authored 105 publications receiving 12720 citations. Previous affiliations of Mario Albrecht include Graz University of Technology & Greifswald University Hospital.
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Journal ArticleDOI
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
Jochen Hampe,Andre Franke,Philip Rosenstiel,Philip Rosenstiel,Andreas Till,Markus Teuber,Klaus Huse,Mario Albrecht,Gabriele Mayr,Francisco M. De La Vega,Jason C Briggs,Simone Günther,Natalie J. Prescott,Clive M. Onnie,Robert Häsler,Bence Sipos,Ulrich R. Fölsch,Thomas Lengauer,Matthias Platzer,Christopher G. Mathew,Michael Krawczak,Stefan Schreiber +21 more
TL;DR: Data suggest that the underlying biological process may be specific to Crohn disease, and that marker rs2241880, a coding SNP (T300A), carries virtually all the disease risk exerted by the ATG16L1 locus.
Journal ArticleDOI
Computing topological parameters of biological networks
TL;DR: The versatile Cytoscape plugin NetworkAnalyzer computes and displays a comprehensive set of topological parameters, which includes the number of nodes, edges, and connected components, the network diameter, radius, density, centralization, heterogeneity, and clustering coefficient, and the characteristic path length.
Journal ArticleDOI
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Andre Franke,Tobias Balschun,Tom H. Karlsen,Jurgita Sventoraityte,Susanna Nikolaus,Gabriele Mayr,Francisco S. Domingues,Mario Albrecht,Michael Nothnagel,David Ellinghaus,Christian Sina,Clive M. Onnie,Rinse K. Weersma,Pieter C. F. Stokkers,Cisca Wijmenga,Maria Gazouli,David P. Strachan,Wendy L. McArdle,Severine Vermeire,Paul Rutgeerts,Philip Rosenstiel,Michael Krawczak,Morten H. Vatn,Christopher G. Mathew,Stefan Schreiber +24 more
TL;DR: A genome-wide association study with 440,794 SNPs genotyped in 1,167 individuals with UC and 777 healthy controls strongly suggests that defective IL10 function is central to the pathogenesis of the UC subtype of IBD.
Journal ArticleDOI
Genetic variation in DLG5 is associated with inflammatory bowel disease
Monika Stoll,Brit Corneliussen,Christine M. Costello,Georg H. Waetzig,Bjorn Mellgard,W. Andreas Koch,Philip Rosenstiel,Mario Albrecht,Peter J. P. Croucher,Dirk Seegert,Susanna Nikolaus,Jochen Hampe,Thomas Lengauer,Stefan Pierrou,Ulrich R. Foelsch,Christopher G. Mathew,Maria Lagerström-Fermér,Stefan Schreiber +17 more
TL;DR: A significant difference in association of the 113A DLG5 variant with Crohn disease is found in affected individuals carrying the risk- associated CARD15 alleles versus those carrying non-risk-associated CARD 15 alleles, suggestive of a complex pattern of gene-gene interaction betweenDLG5 and CARD15, reflecting the complex nature of polygenic diseases.
Journal ArticleDOI
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment
Simon Reiss,Ilka Rebhan,Perdita Backes,Inés Romero-Brey,Holger Erfle,Petr Matula,Petr Matula,Petr Matula,Lars Kaderali,Marion Poenisch,Hagen Blankenburg,Marie Sophie Hiet,Thomas Longerich,Sarah Diehl,Fidel Ramírez,Tamas Balla,Karl Rohr,Karl Rohr,Artur Kaul,Sandra Bühler,Rainer Pepperkok,Thomas Lengauer,Mario Albrecht,Roland Eils,Roland Eils,Peter Schirmacher,Volker Lohmann,Ralf Bartenschlager +27 more
TL;DR: Analysis suggests that the direct activation of a lipid kinase by HCV NS5A contributes critically to the integrity of the membranous viral replication complex.