Showing papers by "Sébastien Vidal published in 2007"
155 citations
TL;DR: The synthesis of propargylated pentaerythrityl phosphodiester oligomers (PePOs) was achieved using a DNA synthesizer with a bis-propargylator-based phosphoramidite and the IC50 values measured are 10-20 times better than for monovalent l-fucose and denotate for a "macromolecular" effect rather than a "cluster" effect.
101 citations
Patent•
26 Apr 2007TL;DR: In this paper, a click chemistry reaction between an azide function on a molecule of interest and an alkyne function on the oligonucleotide was used to generate nucleotide derivatives.
Abstract: Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.
12 citations
Patent•
26 Apr 2007TL;DR: In this article, a click chemistry reaction between an azide function on the molecule of interest and an alkyne function was used for grafted oligonucleotides for biological investigation and for cell targeting.
Abstract: Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a 'click chemistry' reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.
9 citations