Seiichi Orikasa

TL;DR: The data in human renal cell carcinoma suggest that infiltration of tumor tissue by T cells itself does not denote the efficacy of antitumor immunity because of its dependence on the biological malignancy of tumor cells, but infiltration of tumors by CD8(+) T cells bearing more pronounced proliferative activity could reflect effective antitumors immunity.

TL;DR: It is shown that MITF-M transactivates its own promoter (Mpromoter) by interacting with LEF-1, as judged by transient expression assays and in vitro protein-protein binding assays, whereas no transactivation of the M promoter was detected with MITf-M alone or with the combination of MITF -M and dominant-negative LEF1 that lacks the β-catenin-binding domain.

TL;DR: In conclusion, overexpression of aromatase, possibly attributable to abnormal gene regulation, may result in estrogen production in situ and play a role in the induction or development of human prostatic disorders.

TL;DR: Improved gray scale echograms in transrectal ultrasonography clearly can visualize the anatomical structure of and pathological changes in the prostatic gland.

TL;DR: Clinical experience with gamma‐knife radiosurgery (GK) in patients with brain metastasis from renal cell carcinoma (RCC) shows the value of this less invasive treatment modality.