Open AccessJournal Article
Proliferative activity of intratumoral CD8(+) T-lymphocytes as a prognostic factor in human renal cell carcinoma: clinicopathologic demonstration of antitumor immunity.
Osamu Nakano,Makoto Sato,Yoshitaka Naito,Kenichi Suzuki,Seiichi Orikasa,Masataka Aizawa,Yasuyoshi Suzuki,Ichirou Shintaku,Hiroshi Nagura,Haruo Ohtani +9 more
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TLDR
The data in human renal cell carcinoma suggest that infiltration of tumor tissue by T cells itself does not denote the efficacy of antitumor immunity because of its dependence on the biological malignancy of tumor cells, but infiltration of tumors by CD8(+) T cells bearing more pronounced proliferative activity could reflect effective antitumors immunity.Abstract:
Tumor-infiltrating lymphocytes, particularly CD8(+) T cells, could be a manifestation of antitumor immunity. We clinicopathologically analyzed the biological significance of tumor-infiltrating lymphocytes in 221 patients with renal cell carcinoma without preoperative treatments. More abundant infiltration of tumor tissue not only by CD8(+) but also CD4(+) T cells was associated with shorter survival of the patients, because of the positive correlation between the number of lymphocytes and representative tumor grade factors. This suggests that immune cell reactions are more pronounced as the tumor grade/biological malignancy progresses, probably because of increased antigenicity of tumor cells. We next analyzed the proliferative activity of CD8(+) T cells that infiltrated in tumor cell nests, which could also reflect antitumor immunity. Higher labeling index of Ki-67, a proliferation-associated antigen, among CD8(+) T cells in contact to tumor cells was associated with a longer survival by both uni- and multivariate analyses. Our data in human renal cell carcinoma suggest that infiltration of tumor tissue by T cells itself does not denote the efficacy of antitumor immunity because of its dependence on the biological malignancy of tumor cells, but infiltration of tumor tissue by CD8(+) T cells bearing more pronounced proliferative activity could reflect effective antitumor immunity. This concept would be important for future immunotherapy of human cancer.read more
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Journal ArticleDOI
The immune contexture in human tumours: impact on clinical outcome
Wolf H. Fridman,Franck Pagès,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Jérôme Galon +5 more
TL;DR: In this Opinion article, the context-specific nature of infiltrating immune cells can affect the prognosis of patients is discussed.
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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
Lin Zhang,Jose R. Conejo-Garcia,Dionyssios Katsaros,Phyllis A. Gimotty,Marco Massobrio,Giorgia Regnani,Antonis Makrigiannakis,Heidi J. Gray,Katia Schlienger,Michael N. Liebman,Stephen C. Rubin,George Coukos +11 more
TL;DR: The presence of intratumoral T cells correlates with improved clinical outcome in advanced ovarian carcinoma and was associated with increased expression of interferon-gamma, interleukin-2, and lymphocyte-attracting chemokines within the tumor.
Journal ArticleDOI
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
Eiichi Sato,Sara H. Olson,Jiyoung Ahn,Brian N. Bundy,Hiroyoshi Nishikawa,Feng Qian,Achim A. Jungbluth,Denise Frosina,Sacha Gnjatic,Christine B. Ambrosone,James L. Kepner,Tosin Odunsi,Gerd Ritter,Shashikant Lele,Yao-Tseng Chen,Haruo Ohtani,Lloyd J. Old,Kunle Odunsi +17 more
TL;DR: It is concluded that intraepithelial CD8+ TILs and a high CD8-/Treg ratio are associated with favorable prognosis in epithelial ovarian cancer.
Journal ArticleDOI
The tumor microenvironment and its role in promoting tumor growth.
TL;DR: The tumor microenvironment is created by the tumor and dominated by tumor-induced interactions, and various immune effector cells are recruited to the tumor site, their anti-tumor functions are downregulated, largely in response to tumor-derived signals.
Journal ArticleDOI
Cytokines in cancer pathogenesis and cancer therapy
TL;DR: The mixture of cytokines that is produced in the tumour microenvironment has an important role in cancer pathogenesis and provides new opportunities for improving cancer immunotherapy.
References
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TNM classification of malignant tumours
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Journal ArticleDOI
A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone.
Steven A. Rosenberg,Michael T. Lotze,Linda M. Muul,Alfred E. Chang,Fred P. Avis,Susan F. Leitman,W. Marston Linehan,Cary N. Robertson,Roberta E. Lee,Joshua T. Rubin,Claudia A. Seipp,Colleen Simpson,Donald E. White +12 more
TL;DR: This immunotherapeutic approach can result in marked tumor regression in some patients for whom no other effective therapy is available at present, and determining its ultimate role in cancer therapy awaits further attempts to increase the therapeutic efficacy of treatment and decrease its toxicity and complexity.
Journal ArticleDOI
Prognostic significance of morphologic parameters in renal cell carcinoma.
TL;DR: Nuclear grade was the most significant prognostic criterion for the outcome of State I renal cell carcinoma, more effective than each of the other parameters in predicting development of distant metastasis following nephrectomy.
Journal Article
CD8+ T Cells Infiltrated within Cancer Cell Nests as a Prognostic Factor in Human Colorectal Cancer
Yoshitaka Naito,Kazuya Saito,Kenichi Shiiba,Akio Ohuchi,Katsunori Saigenji,Hiroshi Nagura,Haruo Ohtani +6 more
TL;DR: The data suggested that human colorectal cancer tissue was infiltrated by various numbers of T cells that had cytotoxic phenotype, contributing to a better survival of patients, and could be a novel prognostic factor.
Journal ArticleDOI
Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients.
Peter P. Lee,Cassian Yee,Peter A. Savage,Lawrence Fong,Dirk G. Brockstedt,Jeffrey S. Weber,Denise L. Johnson,Susan M. Swetter,John A. Thompson,Philip D. Greenberg,Mario Roederer,Mark M. Davis +11 more
TL;DR: It is demonstrated that systemic TAA-specific T-cell responses can develop de novo in cancer patients, but that antigen-specific unresponsiveness may explain why such cells are unable to control tumor growth.
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