Sekhar Surapaneni

TL;DR: Following oral administration, pomalidomide was well absorbed, with parent compound being the predominant circulating component, and metabolites were eliminated primarily in urine.

TL;DR: Following oral administration, lenalidomide is highly absorbed and bioavailable, metabolized minimally, and eliminated predominantly via urinary excretion in the unchanged form in humans.

TL;DR: Apremilast is a novel, orally available small molecule that specifically inhibits PDE4 and thus modulates multiple pro- and anti-inflammatory mediators, and is currently under clinical development for the treatment of psoriasis and psoriatic arthritis.

TL;DR: The immune stimulatory effects of lenalidomide, administrated to mice in doses, which provided comparable pharmacokinetics to human patients, on the potency of a novel fusion DNA lymphoma vaccine were investigated and results confirm and extend results from other models describing the effect of len Khalidomide on enhancing T-cell immunity.

TL;DR: It is submitted that radiolabeled animal ADME studies still provide a definitive and irreplaceable component of the understanding of the in vivo actions and behaviors of drugs and should continue to be performed prior to the exposure of large numbers of human subjects to investigative drugs.