A
Anastasia Parton
Researcher at Celgene
Publications - 14
Citations - 1045
Anastasia Parton is an academic researcher from Celgene. The author has contributed to research in topics: Pomalidomide & Apremilast. The author has an hindex of 8, co-authored 12 publications receiving 899 citations.
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Journal ArticleDOI
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.
Peter H. Schafer,Anastasia Parton,Anita Gandhi,Lori Capone,Mary Adams,Lei Wu,Justin B. Bartlett,Loveland Ma,Amos Gilhar,Cheung Yf,George S. Baillie,Houslay,Man Hw,G. W. Muller,D. I. Stirling +14 more
TL;DR: The inhibitory effects of apremilast on pro‐inflammatory responses of human primary peripheral blood mononuclear cells, polymorphonuclear Cells, natural killer cells and epidermal keratinocytes were explored in vitro, and in a preclinical model of psoriasis.
Journal ArticleDOI
Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity.
Peter H. Schafer,Anastasia Parton,Lori Capone,Dorota Cedzik,Helen Brady,Jilly F. Evans,Man Hw,G.W. Muller,D.I. Stirling,Rajesh Chopra +9 more
TL;DR: The pharmacological effects of apremilast are consistent with those of a targeted PDE4 inhibitor, with selective effects on innate immune responses and a wide therapeutic index compared to its gastrointestinal side effects.
Journal ArticleDOI
Absorption, metabolism and excretion of [14C]pomalidomide in humans following oral administration
Matthew Hoffmann,Claudia Kasserra,Josephine Reyes,Peter H. Schafer,Jolanta Kosek,Lori Capone,Anastasia Parton,Heasook Kim-Kang,Sekhar Surapaneni,Gondi Kumar +9 more
TL;DR: Following oral administration, pomalidomide was well absorbed, with parent compound being the predominant circulating component, and metabolites were eliminated primarily in urine.
Journal ArticleDOI
Lenalidomide inhibits proliferation of Namalwa CSN.70 cells and interferes with Gab1 phosphorylation and adaptor protein complex assembly.
Anita Gandhi,Jian Kang,Syedah D Naziruddin,Anastasia Parton,Peter H. Schafer,David I. Stirling +5 more
TL;DR: It is reported that lenalidomide inhibits proliferation of chromosome 5 deleted hematopoietic tumor cell lines in vitro, whether from the B cell, T cell, or myeloid lineage, and evidence for the mechanism of action is provided.
Journal ArticleDOI
Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.
Peter H. Schafer,Francesca Truzzi,Anastasia Parton,Lei Wu,Jolanta Kosek,Ling-Hua Zhang,Gerald Horan,Annalisa Saltari,M. Quadri,Roberta Lotti,Alessandra Marconi,Carlo Pincelli +11 more
TL;DR: PDE4 expression is up-regulated in psoriatic dermis as compared with normal skin, with particular regard to fibroblasts, and the study reveals that the PDE4/CD271 complex could be important in modulating fibroblast functions.