Sen Li

TL;DR: A therapeutic strategy using vIL-10-engineered MSCs to prevent IR injury in lung transplantation seems promising and ISOL (in situ oligonucleotide ligation for DNA fragmentation detection) and caspase-3 staining demonstrated significantly (p < 0.05) fewer apoptotic cells in MSC-vIL10-treated lungs.

TL;DR: Age-dependent increases in PDGFR-alpha may alter VSMC proliferation, and when coupled with resistance to apoptosis could contribute to exaggerated neointima formation in aging animals.

TL;DR: The demonstration that tolerance can be achieved with minimal preconditioning provides a rationale for application to large animals and humans and suggests that although composite tissue allografts may have a significant skin component (and are therefore felt to be highly antigenic), protocols used to induce tolerance to organ transplants may be equally applicable to composite-tissue allotransplantation.

TL;DR: TNFRSF25 agonists expand Tregs in vivo and delay allograft rejection in a mouse model of fully major histocompatibility complex–mismatched ectopic heart transplants.

TL;DR: It is concluded that substrate specificity of the proteasome changes during cold ischemia and that proteasomesome inhibition preserves the physiological ubiquitin-protein conjugate pool during organ preservation.