Showing papers by "Senthamaraikannan Kabilan published in 2016"
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TL;DR: It can be concluded from the study that 9b is the most active compound from the series against PC-3 and LNCaP cell lines.
Abstract: Antiandrogens are a novel class of anticancer agents that inhibit cancer cell proliferation and induce apoptosis in various cell lines. To find the lead compound from the oxobenzimidazole derivatives, receptor-ligand docking studies were initially performed using Schrodinger software. The best fit molecules were synthesized and characterized through IR, 1H-NMR, 13C-NMR and HRMS analyses. The structure of compound (9b) was further confirmed by single-crystal XRD analysis. The cell viability of the compounds was determined by MTT assay to find IC50 values against prostate cancer and breast cancer cell lines (PC-3, LNCaP, MCF-7 and MDA-MB-231). The ADME/T property studies were performed to rationalize the inhibitory properties of these compounds. It can be concluded from the study that 9b is the most active compound from the series against PC-3 and LNCaP cell lines.
27 citations
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TL;DR: In this article, the authors show that substantial reduction in friction and wear can be achieved by mixing various proportions of mineral base oils and esters, without adding any conventional antiwear additives.
17 citations
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TL;DR: In this paper, the authors have synthesized (E)-1-(2, 6-bis (4-methoxyphenyl)-3, 3-dimethylpiperidine-4-ylidene)-2-(3, 5dimethyl-1H-pyrazol-1yl) pyrazin-2-yl) hydrazine (PM6) using FT-IR, FT-Raman, 1 H NMR, 13 C NMR techniques.
16 citations
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TL;DR: A series of 1,3-thiazin-4-one derivatives containing a piperidyl ring (7-16) were designed and synthesized efficiently by thioamide and acetylene diester cyclization reaction via aminolysis of the ester group and the elimination of an alcohol molecule.
Abstract: GRAPHICAL ABSTRACT ABSTRACT A novel series of 1,3-thiazin-4-one derivatives containing a piperidyl ring (7–16) were designed and synthesized efficiently by thioamide and acetylene diester cyclization reaction via aminolysis of the ester group and the elimination of an alcohol molecule. The structures of all the novel compounds were established by their FTIR, Mass, 1H NMR, and 13C NMR spectral techniques. The newly synthesized compounds (7–16) were studied for their in vitro anticancer activity against human liver cancer cell lines Hep G2 using MTT assay. The IC50 values of the tested compounds were ranging in between 7.48 ± 0.71 and 56.57 ± 1.37 µM. Further, the apoptosis evaluation by the mitochondrial membrane potential using JC-1 dye was carried out and the results are in good agreement with the cytotoxicity studies.
3 citations
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TL;DR: In this paper, the methoxy-phenyl ring is oriented at an angle of 9.5° with respect to the thiaßole ring, which forms C(7) chains propagating along the crystal.
2 citations
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TL;DR: The title iso-indole, C18H8N3O2S, crystallizes with two independent mol-ecules (A and B) in the asymmetric unit whose geometrical features are similar as discussed by the authors.
2 citations
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TL;DR: The title acetamide, C11H9ClN2OS, crystallizes with two independent mol-ecules in the asymmetric unit whose geometrical features are similar as mentioned in this paper.
2 citations
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TL;DR: In the case of acetamide, C11H8Cl2N2OS, the chloro-phenyl ring is oriented at an angle of 7.1° with respect to the thia-zole ring as mentioned in this paper.
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TL;DR: In this paper, all C, N and O atoms of the title compound, C13H13ClN2O, lie in a common plane (r.m.s. deviation = 0.096