S
Seon-Won Kim
Researcher at Gyeongsang National University
Publications - 116
Citations - 4716
Seon-Won Kim is an academic researcher from Gyeongsang National University. The author has contributed to research in topics: Escherichia coli & Mevalonate pathway. The author has an hindex of 35, co-authored 109 publications receiving 4060 citations. Previous affiliations of Seon-Won Kim include University of California, Berkeley.
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Journal ArticleDOI
Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production.
Seon-Won Kim,Jay D. Keasling +1 more
TL;DR: Given the low final densities of cells expressing dxs from IPTG-inducible promoters, the low lycopene production was probably due to the metabolic burden of plasmid maintenance and an excessive drain of central metabolic intermediates.
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Low-copy plasmids can perform as well as or better than high-copy plasmids for metabolic engineering of bacteria.
TL;DR: Low-copy plasmids may be useful in metabolic engineering applications, particularly when one or more of the substrates used in the recombinant pathway are required for normal cellular metabolism.
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Combinatorial expression of bacterial whole mevalonate pathway for the production of β-carotene in E. coli
Sang-Hwal Yoon,Sook-Hee Lee,Amitabha Das,Hee-Kyoung Ryu,Hee-Jeong Jang,Jae-Yean Kim,Deok-Kun Oh,Jay D. Keasling,Seon-Won Kim +8 more
TL;DR: The recombinant E. coli strains - MG1655, DH5alpha, S17-1, XL1-Blue and BL21 - the DH5 alpha was found to be the best beta-carotene producer and glycerol as the carbon source for beta- carotene production was foundto be superior to glucose, galactose, xylose and maltose.
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An update on microbial carotenoid production: application of recent metabolic engineering tools.
TL;DR: Recent progress made in metabolic engineering of non-carotenogenic microorganisms with particular focus on the potential of Escherichia coli for improved carotenoid productivity are described.
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Metabolic engineering of Escherichia coli for α-farnesene production.
Chonglong Wang,Sang-Hwal Yoon,Hui-Jeong Jang,Young-Ryun Chung,Jae-Yean Kim,Eui-Sung Choi,Seon-Won Kim +6 more
TL;DR: The engineered E. coli strain was able to produce 380.0 mg/L of α-farnesene, which is an approximately 317-fold increase over the initial production of 1.2mg/L, and an additional increase was achieved by the protein fusion of FPP synthase and α- fernesene synthase.