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Serge Koscielny
Researcher at Institut Gustave Roussy
Publications - 152
Citations - 8999
Serge Koscielny is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 50, co-authored 151 publications receiving 8338 citations. Previous affiliations of Serge Koscielny include Institut de Chimie des Substances Naturelles & University of Paris-Sud.
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Journal ArticleDOI
Prediction of cancer outcome with microarrays: a multiple random validation strategy.
TL;DR: Data is reanalysed from the seven largest published studies that have attempted to predict prognosis of cancer patients on the basis of DNA microarray analysis to study the stability of the molecular signature and the proportion of misclassifications.
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Hyperprogressive Disease in Patients With Advanced Non-Small Cell Lung Cancer Treated With PD-1/PD-L1 Inhibitors or With Single-Agent Chemotherapy
Roberto Ferrara,Laura Mezquita,M. Texier,J. Lahmar,Clarisse Audigier-Valette,Laurent Tessonnier,Julien Mazieres,Gérard Zalcman,Solenn Brosseau,Sylvestre Le Moulec,L. Leroy,Boris Duchemann,Corentin Lefebvre,Remi Veillon,Virginie Westeel,Serge Koscielny,Stéphane Champiat,Charles Ferté,David Planchard,Jordi Remon,Marie Eve Boucher,Anas Gazzah,Julien Adam,Emilio Bria,Giampaolo Tortora,Jean-Charles Soria,Benjamin Besse,Benjamin Besse,Caroline Caramella +28 more
TL;DR: It is suggested that HPD is more common with PD-1/PD-L1 inhibitors compared with chemotherapy in pretreated patients with NSCLC and is also associated with high metastatic burden and poor prognosis in patients treated with PD.
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False discovery rate, sensitivity and sample size for microarray studies
TL;DR: The purpose of this paper is to explain in simple ways why the shift from P-value to FDR for statistical assessment of microarray data is necessary, to elucidate the determining factors of FDR and, for a two-sample comparative study, to discuss its control via sample size at the design stage.
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Breast cancer: Relationship between the size of the primary tumour and the probability of metastatic dissemination
Serge Koscielny,M. Tubiana,M. G. Lê,Alain-Jacques Valleron,H. Mouriesse,Geneviève Contesso,Danièle Sarrazin +6 more
TL;DR: It was found that the threshold volume is strongly correlated with the number of involved lymph nodes and the histological grading, and suggests the existence for each tumour of a critical volume at which the first remote metastasis is initiated.
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Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients.
R. de Crevoisier,Jean-Henri Bourhis,Christian Domenge,Pierre Wibault,Serge Koscielny,Antoine Lusinchi,Gérard Mamelle,François Janot,Morbize Julieron,A. M. Leridant,Patrick Marandas,J.P. Armand,Guy Schwaab,Bernard Luboinski,François Eschwege +14 more
TL;DR: Full-dose reirradiation combined with chemotherapy was feasible in patients with inoperable HNC, and the incidence and severity of late toxicity was markedly increased in comparison to that observed after the first irradiation.