F
François Eschwege
Researcher at Institut Gustave Roussy
Publications - 155
Citations - 6865
François Eschwege is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Radiation therapy & Cancer. The author has an hindex of 41, co-authored 155 publications receiving 6625 citations. Previous affiliations of François Eschwege include University of Paris-Sud.
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Journal ArticleDOI
Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups.
Harry Bartelink,F. Roelofsen,François Eschwege,Ph. Rougier,J.F. Bosset,Dionisio González González,Didier Peiffert,M. van Glabbeke,Marianne Pierart +8 more
TL;DR: The concomitant use of radiotherapy and chemotherapy resulted in a significantly improved locoregional control rate and a reduction of the need for colostomy in patients with locally advanced anal cancer without a significant increase in late side effects.
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Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer
David M. Brizel,Todd H. Wasserman,Michael Henke,Vratislav Strnad,Volkar Rudat,Alain Monnier,François Eschwege,Jay Zhang,Lesley Russell,Wolfgang Oster,Rolf Sauer +10 more
TL;DR: With and without amifostine, 2-year local-regional control, disease-free survival, and overall survival were 58% versus 63, 53% versus 57%, and 71% versus 66%, respectively, while Antitumor treatment efficacy was preserved.
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Full-dose reirradiation for unresectable head and neck carcinoma: experience at the Gustave-Roussy Institute in a series of 169 patients.
R. de Crevoisier,Jean-Henri Bourhis,Christian Domenge,Pierre Wibault,Serge Koscielny,Antoine Lusinchi,Gérard Mamelle,François Janot,Morbize Julieron,A. M. Leridant,Patrick Marandas,J.P. Armand,Guy Schwaab,Bernard Luboinski,François Eschwege +14 more
TL;DR: Full-dose reirradiation combined with chemotherapy was feasible in patients with inoperable HNC, and the incidence and severity of late toxicity was markedly increased in comparison to that observed after the first irradiation.
Journal ArticleDOI
BCR-ABL down-regulates the DNA repair protein DNA-PKcs.
Eric Deutsch,Aymeric Dugray,Bassam Abdulkarim,Elisabetta Marangoni,Laurence Maggiorella,Sabine Vaganay,Radia M'Kacher,Setha Douc Rasy,François Eschwege,William Vainchenker,Ali G. Turhan,Jean Bourhis +11 more
TL;DR: The conjunction of a major DNA repair deficiency and a resistance to apoptosis, both induced by BCR-ABL, provides a new mechanism to explain how secondary genetic alterations can accumulate in CML, eventually leading to blast crisis.
Journal ArticleDOI
Long-Term Disease-Free Survivors in Metastatic Undifferentiated Carcinoma of Nasopharyngeal Type
A. Fandi,Mounir Bachouchi,Nacer Azli,A. Taamma,Hammouda Boussen,Pierre Wibault,François Eschwege,Jean-Pierre Armand,Jonathan Simon,Esteban Cvitkovic +9 more
TL;DR: The data support a curative role for chemotherapy in metastatic UCNT and are a major incentive to continue research for better combinations to increase the percentage of patients with metastaticUCNT who attain complete responses and long-term survival.