S
Serge Laroche
Researcher at Université Paris-Saclay
Publications - 112
Citations - 9718
Serge Laroche is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Long-term potentiation & Dentate gyrus. The author has an hindex of 45, co-authored 111 publications receiving 9190 citations. Previous affiliations of Serge Laroche include Centre national de la recherche scientifique & University of Paris-Sud.
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A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories.
Matt Jones,M.L. Errington,Pim J. French,A. Fine,Timothy V. P. Bliss,Sonia Garel,Patrick Charnay,Bruno Bozon,Serge Laroche,Sabrina Davis +9 more
TL;DR: It is shown that whereas mutant mice exhibit early LTP in the dentate gyrus, late LTP is absent when measured 24 and 48 hours after tetanus in the freely moving animal, and Zif268 is essential for the transition from short-to-long-term synaptic plasticity and for the expression of long-term memories.
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The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate Gyrus In Vivo
TL;DR: It is suggested that Elk-1 forms an important link in the MAP kinase pathway to transduce signals from the cell surface to the nucleus to activate the genetic machinery necessary for the maintenance of synaptic plasticity in the dentate gyrus.
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New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment.
TL;DR: It is established that newborn cells in the dentate gyrus contribute to the expression of the promnesic effects of behavioural enrichment, and they provide further support for the idea that adult‐generated neurons participate in modulating memory function.
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Plasticity at hippocampal to prefrontal cortex synapses: dual roles in working memory and consolidation.
TL;DR: The available evidence suggests that functional interactions between the hippocampus and prefrontal cortex in cognition and memory are more complex than previously anticipated, with the possibility for bidirectional regulation of synaptic strength as a function of the specific demands of tasks.
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Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase in hippocampal circuitry is required for consolidation and reconsolidation of recognition memory.
TL;DR: The data show that the MAPK kinase pathway is required for both consolidation and reconsolidation of long-term recognition memory, and that this is associated with hyperphosphorylation of ERK in different subregions of the entorhinal cortex—hippocampal circuitry.