S
Seth H. Pincus
Researcher at LSU Health Sciences Center New Orleans
Publications - 88
Citations - 2185
Seth H. Pincus is an academic researcher from LSU Health Sciences Center New Orleans. The author has contributed to research in topics: Antibody & Ricin. The author has an hindex of 27, co-authored 84 publications receiving 2063 citations. Previous affiliations of Seth H. Pincus include National Institutes of Health & Boston Children's Hospital.
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Journal ArticleDOI
Epitope Mapping and Topology of Baculovirus-Expressed HIV-1 gp160 Determined with a Panel of Murine Monoclonal Antibodies
Yusuf Hakan Abacioglu,Timothy R. Fouts,Jon D. Laman,Eric Claassen,Seth H. Pincus,John P. Moore,Carol A. Roby,Roberta Kamin-Lewis,George K. Lewis +8 more
TL;DR: Results show that rgp160 and rgp120 are folded differently, illustrating the use of this MAb panel to compare epitope topographies of recombination HIV-1 Env proteins, and may aid in the refinement of HIV- 1 Env subunit vaccines.
Journal ArticleDOI
Immunological Characteristics Associated with the Protective Efficacy of Antibodies to Ricin
Massimo Maddaloni,Corrie L. Cooke,Royce A. Wilkinson,Audrey V. Stout,Leta Eng,Seth H. Pincus +5 more
TL;DR: It is demonstrated that immunization with A chain induces greater protection than Immunization with B chain, and an anti-A chain Ab is obtained that bound with high avidity, blocked enzymatic activity, did not neutralize cytotoxicity, and actually enhanced the in vivo toxicity of ricin.
Journal Article
Peptides That Mimic the Group B Streptococcal Type III Capsular Polysaccharide Antigen
TL;DR: Data demonstrate that a peptide mimetic of the GBS capsular polysaccharide is both antigenic and immunogenic and the incorporation of such peptides into vaccine preparations may enhance the efficacy of vaccines in inducing Ab responses to important carbohydrate epitopes.
Journal Article
A Subpopulation of Adherent Accessory Cells Bearing Both I-A and I-E or C Subregion Antigens Is Required for Antigen-Specific Murine T Lymphocyte Proliferation
TL;DR: Data indicate that antigen-specific stimulation of T lymphocyte proliferation requires at least one specific subpopulation of spleen adherent cells that can be phenotypically identified by its expression of Ia antigens and are consistent with the possibility that IaAntigens may be Ir gene products.
Journal Article
Treatment of HIV tissue culture infection with monoclonal antibody-ricin A chain conjugates.
TL;DR: Immunotoxins produced with antibodies that recognize Ag on the surface of HIV-infected cells may have utility in the therapy of AIDS, as measured by the production of viral foci on susceptible monolayer cells.