H
Harold J. Jennings
Researcher at National Research Council
Publications - 137
Citations - 6130
Harold J. Jennings is an academic researcher from National Research Council. The author has contributed to research in topics: Epitope & Sialic acid. The author has an hindex of 44, co-authored 137 publications receiving 6019 citations.
Papers
More filters
Journal ArticleDOI
Structural determination of the sialic acid polysaccharide antigens of Neisseria meningitidis serogroups B and C with carbon 13 nuclear magnetic resonance.
TL;DR: The application of 13-C nuclear magnetic resonance to the analysis of some sialic acid-containing meningococcal polysaccharide antigens is described and complete assignments of the spectra of both the native serogroup B and the de-O-acetylated serogroups C polySaccharides have been made.
Journal ArticleDOI
Immune response to type III group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine.
Dennis L. Kasper,Lawrence C. Paoletti,Michael R. Wessels,Hilde-Kari Guttormsen,Vincent J. Carey,Harold J. Jennings,Carol J. Baker +6 more
TL;DR: Direct coupling of type III GBS polysaccharide to a carrier protein yielded a conjugate vaccine with preserved expression of a highly labile conformational epitope involving sialic acid and enhanced immunogenicity compared with uncoupled CPS.
Journal ArticleDOI
Composition, sequence, and conformation of polymers and oligomers of glucose as revealed by carbon-13 nuclear magentic resonance.
Journal ArticleDOI
Immunogenicity in animals of a polysaccharide-protein conjugate vaccine against type III group B Streptococcus.
Michael R. Wessels,Lawrence C. Paoletti,Dennis L. Kasper,J L DiFabio,F Michon,K Holme,Harold J. Jennings +6 more
TL;DR: The results suggest that this method of conjugation to a carrier protein may be a useful strategy to improve the immunogenicity of the type III group B Streptococcus polysaccharide in human subjects.