S
Seung Bum Lee
Researcher at National Institutes of Health
Publications - 43
Citations - 1205
Seung Bum Lee is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Stem cell & Induced pluripotent stem cell. The author has an hindex of 18, co-authored 34 publications receiving 966 citations.
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Link between Mitochondria and NADPH Oxidase 1 Isozyme for the Sustained Production of Reactive Oxygen Species and Cell Death
TL;DR: Overall, this study shows a signaling link between the mitochondria and Nox1, which is crucial for the sustained accumulation of ROS and cell death in serum withdrawal-induced signaling.
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Engrafted human stem cell–derived hepatocytes establish an infectious HCV murine model
Arnaud Carpentier,Abeba Tesfaye,Virginia Chu,Ila Nimgaonkar,Fang Zhang,Seung Bum Lee,Snorri S. Thorgeirsson,Stephen M. Feinstone,T. Jake Liang +8 more
TL;DR: It is determined that, despite an immature phenotype, differentiated HLCs are permissive to hepatitis C virus (HCV) infection and mount an interferon response to HCV infection in vitro.
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Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development
TL;DR: The knockout of either the EIF5a-1 gene (Eif5a) or of the deoxyhypusine synthase gene (Dhps) caused early embryonic lethality in mice, indicating the essential nature of both eIF5A-1 and deoxy Hypusin synthase in mammalian development.
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Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells
Yohan Kim,Kyojin Kang,Seung Bum Lee,Daekwan Seo,Sangtae Yoon,Sung Joo Kim,Kiseok Jang,Yun Kyung Jung,Kyeong Geun Lee,Valentina M. Factor,Jaemin Jeong,Dongho Choi +11 more
TL;DR: This study is the first report of successful reprogramming of human hepatocytes to a population of proliferating bipotent cells with regenerative potential and provides a platform for personal and stem cell-based regenerative medicine.
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Phospholipase A2 Activity of Peroxiredoxin 6 Promotes Invasion and Metastasis of Lung Cancer Cells
Jin-Nyoung Ho,Seung Bum Lee,Seung-Sook Lee,Sung Hwan Yoon,Ga Young Kang,Sang-Gu Hwang,Hong-Duck Um +6 more
TL;DR: This study is the first to define the functions of the enzymatic activities ofPRDX6 in metastasis and to show the involvement of arachidonic acid in PRDX6 action in intact cells, providing a significant step toward elucidating the role of PRDX 6 in cancer and the mechanism of its action.