Showing papers in "Journal of Hepatology in 2019"

TL;DR: The global prevalence of viral hepatitis remains high, while drug-induced liver injury continues to increase as a major cause of acute hepatitis.

TL;DR: Given the rapidly growing global burden of NAFLD and NASH, efforts must continue to find accurate non-invasive diagnostic and prognostic biomarkers, to develop effective treatments for individuals with advanced NASH and prevention methods for individuals at high risk of NA FLD and progressive liver disease.

TL;DR: Evidence is provided supporting high prevalence of NAFLD and NASH in patients with T2DM around the world and regional and global mean prevalence weighted by population size in each country were estimated and pooled using random-effects meta-analysis.

TL;DR: These Clinical Practice Guidelines review the present knowledge in the field of nutrition in chronic liver disease and promote further research on this topic, with recommendations provided in specific settings such as hepatic encephalopathy, cirrhotic patients with bone disease, patients undergoing liver surgery or transplantation and critically ill cirrhosis patients.

TL;DR: These Clinical Practice Guidelines summarize the available evidence on risk factors, diagnosis, management and risk minimization strategies for drug-induced liver jury.

TL;DR: A computational approach integrating large-scale clinical and imaging modalities, especially radiomic features from contrast-enhanced CT, to predict microvascular invasion (MVI) and clinical outcomes in patients with HCC demonstrates good performance.

TL;DR: Liver cancer remains a major public health concern globally, Though control of hepatitis B and C virus infections has contributed to the decreasing incidence in some regions, an unfavorable trend in countries with a high socio-demographic index is observed.

TL;DR: The objectives of the workshop were to review the existing knowledge on OBI, to identify issues that require further investigation, to highlight both the existing controversial and newly emerging aspects, and ultimately to update the statements previously agreed in 2008.

TL;DR: In this article, the role of both intestinal barrier integrity and microbiota in NASH development was investigated in C57BL/6J mice fed with high-fat diet (HFD) or methionine-choline-deficient diet for 1 week or longer to recapitulate aspects of NASH (steatosis, inflammation, insulin resistance).

TL;DR: Encouraging trends in mortality from ICC and ECC were observed globally, due to trends in risk factors and possibly, in part,due to better disease classification.

TL;DR: It is shown that established blood tests for liver fibrosis can be used in primary care to stratify patients with fatty liver disease, leading to a reduction in unnecessary referrals by 80% and greatly improving the detection of cases of advanced fibrosis and cirrhosis.

TL;DR: Wang et al. as mentioned in this paper provided stimulating glimpses into the evolving liver disease epidemiology, institutional research profiles, funding landscape, and drug development trends in China, with an attempt to compare her status and achievements with those of the United States, European countries, and Japan.

TL;DR: Findings from high-throughput sequencing and gene expression profiling may help in the near future to translate knowledge of HCC biology into clinical practice, and are expected to improve precision medicine for patients with this highly aggressive malignancy.

TL;DR: An update is provided on the regulatory role of autophagy in various aspects of liver pathophysiology, describing the different strategies to manipulate autophagic flux in vivo and discussing the potential to modulate Autophagy as a therapeutic strategy in the context of liver diseases.

TL;DR: The aim of this position paper, authored by two hepatologists (members of ICA) and two nephrologists involved in the study of renal dysfunction in cirrhosis, is to complete the re-classification of HRS initiated by the ICA in 2012 and to update the knowledge on the definition, classification, diagnosis, pathophysiology and treatment of H RS.

TL;DR: This study found that the addition of SIRT with 90yttrium-loaded resin microspheres to sorafenib treatment in people with advanced HCC did not significantly improve overall survival compared with sorafinib treatment alone, however, the results suggest how future studies on this combination therapy in patients withadvanced HCC could be designed.

TL;DR: 5-year graft survival in donation after cardiac death livers treated by conventional cold storage, or by 1-2 h of hypothermic oxygenated perfusion (HOPE) after cold storage suggests that a simple end-ischaemic perfusion approach is very effective and may open the field for safe utilisation of extended DCD liver grafts.

TL;DR: In virally suppressed HBeAg-negative patients, checkpoint blockade was well-tolerated and led toHBsAg decline in most patients and sustained HBsAg loss in one patient.

TL;DR: MDR bacterial infections constitute a prevalent, growing and complex healthcare problem in patients with decompensated cirrhosis and acute-on-chronic liver failure across Europe, negatively impacting on prognosis and strategies aimed at preventing the spread of antibiotic resistance should be urgently evaluated.

TL;DR: It is demonstrated that quantification of hepatitis B core-related antigen in serum correlates with cccDNA amount and activity and could be used to monitor disease progression and develop new antiviral treatments directly targeting the intrahepatic pool of ccc DNA.

TL;DR: Because of impaired surveillance and poor patient compliance, HCC is often detected late in patients with chronic liver disease of alcoholic aetiology, resulting in more advanced HCC that is less amenable to curative treatment.

TL;DR: In this article, the authors analyzed data from patients transplanted for end-stage liver disease between January 2002 and December 2016 using the European Liver Transplant Registry database and compared data between patients with NASH versus other aetiologies.

TL;DR: Downregulating TOX expression improves the antitumor function of CD8+ T cells, which shows synergetic role with anti-PD1 therapy, highlighting a promising strategy for enhancement of cancer immunotherapy.

TL;DR: The concept that inflammation also plays an important role in promoting liver repair and controlling bacterial infection is highlighted, including the roles of extracellular vesicles and microRNAs, as well as inter-organ crosstalk.

TL;DR: The study results suggest that the use of postmortem normothermic regional perfusion helps reduce rates of post-transplant biliary complications and graft loss and allows for the successful transplantation of livers from older cDCD donors of advanced age.

TL;DR: It is shown that intra-tumoral tertiary lymphoid structures are associated with a low risk of early relapse after surgical resection, suggesting that they reflect the existence of in situ, effective anti-t sumor immunity.

TL;DR: Changing trends in recipient and donor age are summarised and age matching between the donor and the recipient should be incorporated into allocation policies with a multistep approach.

TL;DR: After 21 years of longitudinal follow-up, NAFLD was associated with nearly a 2-fold risk of developing cancers, predominantly of liver, gastrointestinal tract and uterus, suggesting thatNAFLD may be a mediator of obesity-cancer association.

TL;DR: Improving LSEC health appears to be a promising approach to prevent NAFLD progression and complications.

TL;DR: The CheckMate 040 study as mentioned in this paper evaluated the safety and efficacy of nivolumab in patients with advanced hepatocellular carcinoma who were refractory to previous sorafenib treatment or chemotherapy.