S
Sha Li
Researcher at Bristol-Myers Squibb
Publications - 10
Citations - 216
Sha Li is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Inverse agonist & Tyrosine kinase 2. The author has an hindex of 5, co-authored 8 publications receiving 107 citations.
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Journal ArticleDOI
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.
James R. Burke,Lihong Cheng,Kathleen M. Gillooly,Joann Strnad,Adriana Zupa-Fernandez,Ian M. Catlett,Yifan Zhang,Elizabeth M. Heimrich,Kim W. McIntyre,Mark D. Cunningham,Julie Carman,Xiadi Zhou,Dana Banas,Charu Chaudhry,Sha Li,Celia D’Arienzo,Anjaneya Chimalakonda,Xiaoxia Yang,Jenny Xie,Jian Pang,Qihong Zhao,Shawn M. Rose,Jinwen Huang,Moslin Ryan M,Stephen T. Wrobleski,David S. Weinstein,Luisa Salter-Cid +26 more
TL;DR: BMS-986165 is a potent oral agent that similarly blocks receptor-stimulated activation of TYK2 allosterically and with high selectivity and potency afforded through optimized binding to a regulatory domain of the protein.
Journal ArticleDOI
Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist
Robert J. Cherney,Cornelius Lyndon A M,Anurag S. Srivastava,Carolyn A. Weigelt,David Marcoux,Jingwu Duan,Qing Shi,Douglas G. Batt,Qingjie Liu,Shiuhang Yip,Dauh-Rurng Wu,Max Ruzanov,John S. Sack,Javed Khan,Jinhong Wang,Melissa Yarde,Mary Ellen Cvijic,Arvind Mathur,Sha Li,David J. Shuster,Purnima Khandelwal,Virna Borowski,Jenny Xie,Mary T. Obermeier,Aberra Fura,Kevin Stefanski,Georgia Cornelius,Joseph A. Tino,John E. Macor,Luisa Salter-Cid,Rex Denton,Qihong Zhao,Percy H. Carter,T. G. Murali Dhar +33 more
TL;DR: Novel tricyclic analogues were designed, synthesized, and evaluated as RORγt inverse agonists, and compound 5 displayed dose-dependent inhibition of IL-17F production in a mouse IL-2/IL-23 stimulated pharmacodynamic model.
Journal ArticleDOI
349 - BMS-986165 is a Highly Potent and Selective Allosteric Inhibitor of TYK2, Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease
Jenny Xie,Kathleen M. Gillooly,Yifan Zhang,Xiaoxia Yang,Adriana Zupa-Fernandez,Lihong Cheng,Joann Strnad,Elizabeth M. Heimrich,Xiaodi Zhou,Jing Chen,Charu Chaudhry,Sha Li,Moslin Ryan M,Stephen T. Wrobleski,James R. Burke +14 more
Journal ArticleDOI
Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach
Qingjie Liu,Douglas G. Batt,Carolyn A. Weigelt,Shiuhang Yip,Dauh-Rurng Wu,Max Ruzanov,John S. Sack,Jinhong Wang,Melissa Yarde,Sha Li,David J. Shuster,Jenny Xie,Tara Sherry,Mary T. Obermeier,Aberra Fura,Kevin Stefanski,Georgia Cornelius,Purnima Khandelwal,Joseph A. Tino,John E. Macor,Luisa Salter-Cid,Rex Denton,Qihong Zhao,T. G. Murali Dhar +23 more
TL;DR: Employing a virtual screening approach, structure-activity relationship optimization of the pyroglutamide moiety led to the identification of compound 18 as a potent and selective RORγt inverse agonist, albeit with poor aqueous solubility.
Journal ArticleDOI
Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization.
Emily C. Cherney,Liping Zhang,Julian Lo,Tram Huynh,Donna D. Wei,Vijaykamal Ahuja,Claude A. Quesnelle,Gary L. Schieven,Alan S. Futran,Gregory A. Locke,Zeyu Lin,L. Monereau,Charu Chaudhry,Jordan M. Blum,Sha Li,Mark Fereshteh,Bifang Li-Wang,Sanjeev Gangwar,Chin Pan,Colin Chong,Xiao Zhu,Shana L. Posy,John S. Sack,Ping Zhang,Max Ruzanov,Mary J. Harner,Fahad Akhtar,Gretchen M. Schroeder,Gregory G. Vite,Brian E. Fink +29 more
TL;DR: A unique class of non-nucleotide small-molecule STING agonists that demonstrate antitumor activity when dosed intratumorally in a syngeneic mouse model are discovered.