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Shafi Mussa

Researcher at John Radcliffe Hospital

Publications -  18
Citations -  2225

Shafi Mussa is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Radial artery & Tetrahydrobiopterin. The author has an hindex of 12, co-authored 17 publications receiving 2163 citations. Previous affiliations of Shafi Mussa include University of Oxford.

Papers
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Journal ArticleDOI

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus Role of NAD(P)H Oxidase and Endothelial Nitric Oxide Synthase

Tomasz J. Guzik, +6 more
- 09 Apr 2002 - 
TL;DR: These observations suggest important roles for NAD(P)H oxidases, endothelial NO synthase uncoupling, and protein kinase C signaling in mediating increased vascular superoxide production and endothelial dysfunction in human diabetes mellitus.
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Tetrahydrobiopterin-dependent preservation of nitric oxide–mediated endothelial function in diabetes by targeted transgenic GTP–cyclohydrolase I overexpression

Nicholas J. Alp, +8 more
- 01 Sep 2003 - 
TL;DR: In this article, the authors investigated the importance and mechanisms of Tetrahydrobiopterin availability in vivo using a novel transgenic mouse model with endothelial-targeted overexpression of the rate-limiting enzyme in BH4 synthesis, guanosine triphosphate-cyclohydrolase I (GTPCH).
Journal Article

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I over-expression

Nicholas J. Alp, +5 more
- 01 Jan 2003 - 
TL;DR: Findings indicate that BH4 is an important mediator of eNOS regulation in diabetes and is a rational therapeutic target to restore NO-mediated endothelium-dependent vasodilatation in Diabetes and other vascular disease states.
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Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.

Shijie Cai, +4 more
- 21 Jul 2005 - 
TL;DR: The results demonstrate that BH4 plays an important role in regulating eNOS activity and its functional protein structure, suggesting that increasing endothelial BH 4 and/or protecting it from oxidation may be a rational therapeutic strategy to restore eN OS function in diabetes.
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Comparative efficacies and durations of action of phenoxybenzamine, verapamil/nitroglycerin solution, and papaverine as topical antispasmodics for radial artery coronary bypass grafting.

Shafi Mussa, +6 more
- 01 Dec 2003 - 
TL;DR: Phenoxybenzamine is an effective agent with a prolonged duration of action, specifically preventing catecholamine mediated vasospasm of radial artery conduits.