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Shailja Singh
Researcher at Jawaharlal Nehru University
Publications - 175
Citations - 2570
Shailja Singh is an academic researcher from Jawaharlal Nehru University. The author has contributed to research in topics: Plasmodium falciparum & Biology. The author has an hindex of 21, co-authored 139 publications receiving 2001 citations. Previous affiliations of Shailja Singh include Shiv Nadar University & University of Delhi.
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Journal ArticleDOI
Identification and Characterization of a Novel Palmitoyl Acyltransferase as a Druggable Rheostat of Dynamic Palmitoylome in L. donovani .
R. Ayana,Preeti Yadav,Rajesh Kumari,Dandugudumula Ramu,Swati Garg,Soumya Pati,Shailja Singh,Shailja Singh +7 more
TL;DR: The findings suggest that LdPAT4 acts as a functional acyltransferase that can regulate palmitoylation of proteins involved in parasite motility and invasion, thus, can serve as a potential target for designing chemotherapeutics in Visceral Leishmaniasis.
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Reduction of Sphingosine Kinase 1 Phosphorylation and Activity in Plasmodium-Infected Erythrocytes
Raj Kumar Sah,Soumya Pati,Monika Saini,Monika Saini,P.A. Boopathi,Sanjay K. Kochar,Dhanpat K. Kochar,Ashis Das,Shailja Singh +8 more
TL;DR: S1P concentration was significantly depleted in uncomplicated malaria cases and was found to be lowest in complicated malaria and thrombocytopenia in both P. falciparum and P. vivax infections.
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Identification and functional characterization of a bacterial homologue of Zeta toxin in Leishmania donovani.
Akriti Srivastava,Swati Garg,Ravi Jain,R. Ayana,Himani Kaushik,Lalit C. Garg,Soumya Pati,Shailja Singh,Shailja Singh +8 more
TL;DR: The presence of prokaryotic‐like‐zeta‐toxin in eukaryotic parasite Leishmania and its association with cell death is demonstrated and could act as a novel anti‐leishmanial chemotherapeutics.
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Pathogen induced subversion of NAD+ metabolism mediating host cell death: a target for development of chemotherapeutics.
Ayushi Chaurasiya,Swati Garg,Ashish Khanna,Chintam Narayana,Ved Prakash Dwivedi,Nishant Joshi,Zill E Anam,Niharika Singh,Jhalak Singhal,Shikha Kaushik,Amandeep Kaur Kahlon,Pallavi Srivastava,Manisha Marothia,Mukesh Kumar,Santosh Kumar,Geeta Kumari,Akshay Munjal,Sonal Gupta,Preeti Singh,Soumya Pati,Gobardhan Das,Ram Sagar,Anand Ranganathan,Shailja Singh +23 more
TL;DR: In this article, the authors showed that inhibition of pathogen-mediated host NAD+ modulation is a way forward for regulation of infection, synthesized and screened some novel compounds that showed inhibition of NAD+-glycohydrolase activity and pathogen infection in the nanomolar range.
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Targeting metacaspase-3 from Plasmodium falciparum towards antimalarial therapy: A combined approach of in-silico and in-vitro investigation.
Bhumika Kumar,Bhumika Kumar,Taj Mohammad,Amaduddin,Amaduddin,Afzal Hussain,Asimul Islam,Faizan Ahmad,Mohamed F. Alajmi,Shailja Singh,Kailash C. Pandey,Md. Imtaiyaz Hassan,Mohammad Abid +12 more
TL;DR: It is proposed that compound H6 is a promising lead scaffold that can be further exploited as a potential inhibitor of PfMCA3 for therapeutic management of malarial infection.