S
Shailja Singh
Researcher at Jawaharlal Nehru University
Publications - 175
Citations - 2570
Shailja Singh is an academic researcher from Jawaharlal Nehru University. The author has contributed to research in topics: Plasmodium falciparum & Biology. The author has an hindex of 21, co-authored 139 publications receiving 2001 citations. Previous affiliations of Shailja Singh include Shiv Nadar University & University of Delhi.
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Journal ArticleDOI
The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes.
Amrita Dawn,Shailja Singh,Kunal R. More,Faiza Amber Siddiqui,Niseema Pachikara,Ghania Ramdani,Gordon Langsley,Chetan E. Chitnis +7 more
TL;DR: This work identifies cAMP as a key regulator that triggers the timely secretion of microneme proteins enabling receptor-engagement and invasion of P. falciparum merozoites and identifies novel targets to inhibit blood stage parasite growth and prevent malaria.
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Plasmodium falciparum Reticulocyte Binding-Like Homologue Protein 2 (PfRH2) Is a Key Adhesive Molecule Involved in Erythrocyte Invasion
Tajali Sahar,K. Sony Reddy,Mitasha Bharadwaj,Alok Kumar Pandey,Shailja Singh,Chetan E. Chitnis,Deepak Gaur +6 more
TL;DR: PfRH2a/2b plays a key role in erythrocyte invasion and its conserved receptor-binding domain deserves attention as a promising candidate for inclusion in a blood-stage malaria vaccine.
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Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification
Santanu Hati,Sayantan Tripathy,Pratip Kumar Dutta,Rahul Agarwal,Ramprasad Srinivasan,Ashutosh Singh,Shailja Singh,Subhabrata Sen +7 more
TL;DR: Design and synthesis of a library of compounds bearing spiro[pyrrolidine-3, 3´-oxindole] motifs that demonstrated exceptional inhibitory activity against the proliferation of MCF-7 breast cancer cells are reported.
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Ca(2+) -mediated exocytosis of subtilisin-like protease 1: a key step in egress of Plasmodium falciparum merozoites.
TL;DR: The role of intracellular Ca2+ in regulation of egress of P. falciparum merozoites from schizonts is tested and novel targets for development of drugs that block egress and limit parasite growth are identified.
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Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.
Daniel Y. Bargieri,Daniel Y. Bargieri,Sabine Thiberge,Chwen L. Tay,Alison F. Carey,Alison F. Carey,Alice Rantz,Florian Hischen,Audrey Lorthiois,Ursula Straschil,Pallavi Singh,Shailja Singh,Tony Triglia,Takafumi Tsuboi,Alan F. Cowman,Alan F. Cowman,Chetan E. Chitnis,Pietro Alano,Jake Baum,Gabriele Pradel,Catherine Lavazec,Robert Ménard +21 more
TL;DR: Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites, indicating that motor-binding TRAP family members function not just in parasite motility and cell invasion but also in membrane disruption and cell egress.