Shajna Begum

TL;DR: It is demonstrated that type I protein kinase A is redoxactive, forming an interprotein disulfide bond between its two regulatory RI subunits in response to cellular hydrogen peroxide, which causes a subcellular translocation and activation of the kinase, resulting in phosphorylation of established substrate proteins.

TL;DR: The observation of widespread protein-protein disulfides indicates that these oxidative associations are likely to be fundamental in how cells respond to redox changes.

TL;DR: A novel biotinylated derivative of dimedone is synthesized, keeping the dione cassette required for sulfenate reactivity but adding the functionality of a biotin tag, highlighting the protein sulfenates as oxygen sensors in hearts loaded and subjected to hypoxia.

TL;DR: Type II collagen synthesis in articular cartilage is down-regulated at skeletal maturity and reactivated in osteoarthritis in attempted repair and that activin A may be an anabolic factor in cartilage.

TL;DR: The differences observed in the elderly group included down-regulation of regulatory myosin light chains, particularly the phosphorylated isoforms, a higher proportion of myOSin heavy chain isoforms 1 and 2A, and enhanced oxidative and reduced glycolytic capacity.