Shan Wu

TL;DR: Cryo-electron microscopy is used to characterize the structures of yeast nucleoplasmic pre-60S particles affinity-purified using the epitope-tagged assembly factor Nog2, and rich structural information in these structures provides a framework to dissect molecular roles of diverse assembly factors in eukaryotic ribosome assembly.

TL;DR: Cryo-electron microscopy is used to characterize Saccharomyces cerevisiae pre-60S particles purified with epitope-tagged Nmd3 and provide information about functional and mechanistic roles of these assembly factors in the maturation of the 60S ribosomal subunit.

TL;DR: This work characterizes the structure of a type of eukaryotic cotranslational chaperone, the ribosome-associated complex (RAC), and shows that RAC cross-links two ribosomal subunits, through a single long α-helix, to limit the predominant intersubunit rotation required for peptide elongation.

TL;DR: Unexpectedly, GroEL has a specific affinity for the cell structural protein, plectin, which is expressed at abnormally elevated levels on the membranes of tumor cells but not in normal cells, which makes GroEL a superior natural tumor targeting nanocarrier.

TL;DR: The NIR Au-HFt is one of the first native protein-guided Au cluster-based nanomaterials for in vivo biowindow imaging and open new opportunities for kidney disease imaging and theranostic applications.