Y
Yixiao Zhang
Researcher at Rockefeller University
Publications - 32
Citations - 1583
Yixiao Zhang is an academic researcher from Rockefeller University. The author has contributed to research in topics: Ribosome assembly & Mechanosensitive channels. The author has an hindex of 17, co-authored 31 publications receiving 1112 citations. Previous affiliations of Yixiao Zhang include Tsinghua University.
Papers
More filters
Journal ArticleDOI
Structure of the eukaryotic MCM complex at 3.8 A
Ningning Li,Yuanliang Zhai,Yixiao Zhang,Wanqiu Li,Maojun Yang,Jianlin Lei,Bik Kwoon Tye,Ning Gao +7 more
TL;DR: Cryo-electron microscopy reports a near-atomic structure of the MCM2–7 double hexamer purified from yeast G1 chromatin that shows unusual features of the twisted and tilted single hexamers that suggest a concerted mechanism for the melting of origin DNA that requires structural deformation of the intervening DNA.
Journal ArticleDOI
Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes
Shan Wu,Beril Tutuncuoglu,Kaige Yan,Hailey Brown,Yixiao Zhang,Dan Tan,Michael Gamalinda,Yi Yuan,Zhifei Li,Jelena Jakovljevic,Chengying Ma,Jianlin Lei,Meng-Qiu Dong,John L. Woolford,Ning Gao +14 more
TL;DR: Cryo-electron microscopy is used to characterize the structures of yeast nucleoplasmic pre-60S particles affinity-purified using the epitope-tagged assembly factor Nog2, and rich structural information in these structures provides a framework to dissect molecular roles of diverse assembly factors in eukaryotic ribosome assembly.
Journal ArticleDOI
Structural insights into the TRIM family of ubiquitin E3 ligases
Journal ArticleDOI
Molecular basis for the recognition of the human AAUAAA polyadenylation signal.
TL;DR: The cryo-electron microscopy structure of a quaternary complex of human CPSF-160, WDR33, CPSf-30, and an AAUAAA RNA at 3.4-Å resolution is determined, providing an elegant molecular explanation for how PAS sequences are recognized for mRNA 3′-end formation.
Journal ArticleDOI
Kinesin 1 Drives Autolysosome Tubulation
Wanqing Du,Qian Peter Su,Yang Chen,Yueyao Zhu,Dong Jiang,Yueguang Rong,Senyan Zhang,Yixiao Zhang,He Ren,Chuanmao Zhang,Xinquan Wang,Ning Gao,Yanfeng Wang,Lingfei Sun,Yujie Sun,Li Yu +15 more
TL;DR: This study reveals a mechanism by which autolysosome tubulation was generated and it is found that the kinesin motor protein KIF5B is required forAutophagic lysosome Tubulation and that Kif5B drives autoly sosomal tubulation by pulling on the autolySosomal membrane.