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Yanhua Tian
Researcher at Peking Union Medical College
Publications - 41
Citations - 3832
Yanhua Tian is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 17, co-authored 29 publications receiving 2529 citations. Previous affiliations of Yanhua Tian include University of Texas MD Anderson Cancer Center & Jilin University.
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Journal ArticleDOI
A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy.
Yanhua Tian,Suping Li,Jian Song,Tianjiao Ji,Motao Zhu,Gregory J. Anderson,Jingyan Wei,Guangjun Nie +7 more
TL;DR: It is shown that exosomes modified by targeting ligands can be used therapeutically for the delivery of Dox to tumor tissue in BALB/c nude mice, thus having great potential value for clinical applications.
Journal ArticleDOI
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.
Suping Li,Qiao Jiang,Shaoli Liu,Yinlong Zhang,Yanhua Tian,Yanhua Tian,Chen Song,Jing Wang,Yiguo Zou,Gregory J. Anderson,Jing Yan Han,Yung Chang,Yan Liu,Chen Zhang,Liang Chen,Guang-Biao Zhou,Guangjun Nie,Guangjun Nie,Hao Yan,Baoquan Ding,Yuliang Zhao,Yuliang Zhao +21 more
TL;DR: It is demonstrated that intravenously injected DNA nanorobots deliver thrombin specifically to tumor-associated blood vessels and induce intravascular thrombosis, resulting in tumor necrosis and inhibition of tumor growth.
Journal ArticleDOI
Assessment of Blood Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Patients With Non-Small Cell Lung Cancer With Use of a Next-Generation Sequencing Cancer Gene Panel.
Zhijie Wang,Jianchun Duan,Shangli Cai,Miao Han,Hua Dong,Jun Zhao,Bo Zhu,Shuhang Wang,Minglei Zhuo,Jianguo Sun,Qiming Wang,Hua Bai,Jiefei Han,Yanhua Tian,Jing Lu,Tongfu Xu,Xiaochen Zhao,Guoqiang Wang,Xinkai Cao,Fugen Li,Dalei Wang,Chen Yuejun,Yuezong Bai,Jing Zhao,Zhengyi Zhao,Yuzi Zhang,Lei Xiong,Jie He,Shugeng Gao,Jie Wang +29 more
TL;DR: The findings suggest that established NCC-GP150 with an optimized gene panel size and algorithm is feasible for bTMB estimation, which may serve as a potential biomarker of clinical benefit in patients with NSCLC treated with anti–PD-1 and anti-PD-L1 agents.
Journal ArticleDOI
Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity.
Weijia Sun,Chenyang Zhao,Yuheng Li,Liang Wang,Guangjun Nie,Jiang Peng,Aiyuan Wang,Pengfei Zhang,Weiming Tian,Qi Li,Jinping Song,Cheng Wang,Xiaolong Xu,Yanhua Tian,Dingsheng Zhao,Zi Xu,Guohui Zhong,Bingxing Han,Shukuan Ling,Yan Zhong Chang,Yingxian Li +20 more
TL;DR: It is reported that osteoclasts secrete microRNA-enriched exosomes, by which miR-214 is transferred into osteoblasts to inhibit their function, suggesting that exosome-mediated transfer of microRNA plays an important role in the regulation of osteoblast activity.
Journal ArticleDOI
Comutations in DNA Damage Response Pathways Serve as Potential Biomarkers for Immune Checkpoint Blockade.
Zhijie Wang,Jing Zhao,Guoqiang Wang,Fan Zhang,Zemin Zhang,Yuzi Zhang,Hua Dong,Xiaochen Zhao,Jianchun Duan,Hua Bai,Yanhua Tian,Rui Wan,Miao Han,Yan Cao,Lei Xiong,Li Liu,Shuhang Wang,Shangli Cai,Tony Mok,Jie Wang +19 more
TL;DR: Identification of comutations in specific DDR pathways as predictors of superior survival outcomes in response to immune checkpoint blockade provide a clinically convenient approach for estimation of tumor mutational burden and delivery of ICB therapy.