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Shannon H. Lacy
Researcher at University of Rochester
Publications - 13
Citations - 1434
Shannon H. Lacy is an academic researcher from University of Rochester. The author has contributed to research in topics: Myofibroblast & Inflammation. The author has an hindex of 9, co-authored 13 publications receiving 1303 citations. Previous affiliations of Shannon H. Lacy include National Institutes of Health & Cornell University.
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Journal ArticleDOI
Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Delta(9)-desaturase.
J. M. Griinari,Benjamin A. Corl,Shannon H. Lacy,P. Y. Chouinard,K. V. V. Nurmela,Dale E. Bauman +5 more
TL;DR: Results demonstrate that endogenous synthesis of CLA from trans-11 18:1 represented the primary source of CLA in milk fat of lactating cows.
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PPARγ and the Innate Immune System Mediate the Resolution of Inflammation.
Amanda Croasdell,Parker F. Duffney,Nina Kim,Shannon H. Lacy,Patricia J. Sime,Richard P. Phipps +5 more
TL;DR: Novel specialized proresolving mediators—eicosanoids with critical roles in resolution—may act through PPARγ modulation to promote resolution, providing another exciting area of therapeutic potential for this receptor.
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Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Antifibrotic Prostaglandins.
Shannon H. Lacy,Collynn F. Woeller,Thomas H. Thatcher,Stephen J. Pollock,Eric M. Small,Patricia J. Sime,Richard P. Phipps +6 more
TL;DR: Activated fibroblasts communicate with surrounding cells to limit myofibroblast differentiation and maintain homeostasis, which opens the way for future research into extracellular vesicle‐mediated intercellular signaling in the lung.
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Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function.
Thomas H. Thatcher,Marc A. Williams,Stephen J. Pollock,Claire E. McCarthy,Shannon H. Lacy,Richard P. Phipps,Patricia J. Sime +6 more
TL;DR: It is reported that AhR‐deficient mice develop increased allergic responses to the model allergen ovalbumin (OVA), which are driven in part by increased dendritic cell (DC) functional activation, and loss of the AhR was associated with enhanced T‐cell activation by pulmonary DCs and heightened pro‐inflammatory allergic responses.
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Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae
TL;DR: AT-RvD1 protected NTHi-infected mice from weight loss, hypothermia, hypoxemia, and respiratory compromise, and provides the groundwork for further investigation into SPMs as alternatives to immunosuppressive therapies like steroids.