S
Shannon R. Esswein
Researcher at California Institute of Technology
Publications - 16
Citations - 1406
Shannon R. Esswein is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Zika virus & Medicine. The author has an hindex of 7, co-authored 12 publications receiving 642 citations. Previous affiliations of Shannon R. Esswein include Howard Hughes Medical Institute & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Christopher O. Barnes,Claudia A. Jette,Morgan E. Abernathy,Kim Marie A. Dam,Shannon R. Esswein,Harry B. Gristick,Andrey G. Malyutin,Naima G. Sharaf,Kathryn E. Huey-Tubman,Yu E. Lee,Davide F. Robbiani,Davide F. Robbiani,Michel C. Nussenzweig,Michel C. Nussenzweig,Anthony P. West,Pamela J. Bjorkman +15 more
TL;DR: Eight new structures of distinct COVID-19 human neutralizing antibodies 5 in complex with the SARS-CoV-2 spike trimer or RBD are solved and rules for assigning current and future human RBD-targeting antibodies into classes, evaluating avidity effects and suggesting combinations for clinical use are provided.
Journal ArticleDOI
Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain
Boris Brumshtein,Boris Brumshtein,Shannon R. Esswein,Shannon R. Esswein,Lukasz Salwinski,Lukasz Salwinski,Martin L. Phillips,Alan T Ly,Alan T Ly,Duilio Cascio,Duilio Cascio,Michael R. Sawaya,Michael R. Sawaya,David Eisenberg,David Eisenberg +14 more
TL;DR: This work identifies ligands that inhibit amyloid formation by stabilizing the Mcg light chain variable domain dimer and shifting the equilibrium away from the amyloids-prone monomer.
Journal ArticleDOI
Arterial spin-labeling perfusion MRI stratifies progression-free survival and correlates with epidermal growth factor receptor status in glioblastoma.
Xin J Qiao,Benjamin M. Ellingson,Hyun J. Kim,Danny J.J. Wang,Noriko Salamon,Michael Linetsky,Ali R. Sepahdari,B. Jiang,J.J. Tian,Shannon R. Esswein,Timothy F. Cloughesy,Albert Lai,Leia Nghiemphu,Whitney B. Pope +13 more
TL;DR: Qualitative evaluation of arterial spin-labeling CBF maps can be used to stratify survival and predict epidermal growth factor receptor variant III expression in patients with glioblastoma.
Journal ArticleDOI
Formation of Amyloid Fibers by Monomeric Light-chain Variable Domains
Boris Brumshtein,Shannon R. Esswein,Meytal Landau,Christopher M. Ryan,Julian P. Whitelegge,Martin L. Phillips,Duilio Cascio,Michael R. Sawaya,David Eisenberg +8 more
TL;DR: This work identifies the monomeric form of the Mcg immunoglobulin light chain variable domain as the quaternary unit required for amyloid fiber assembly.
Posted ContentDOI
Structural classification of neutralizing antibodies against the SARS-CoV-2 spike receptor-binding domain suggests vaccine and therapeutic strategies
Christopher O. Barnes,Claudia A. Jette,Morgan E. Abernathy,Kim-Marie A. Dam,Shannon R. Esswein,Harry B. Gristick,Andrey G. Malyutin,Naima G. Sharaf,Kathryn E. Huey-Tubman,Yu E. Lee,Davide F. Robbiani,Davide F. Robbiani,Michel C. Nussenzweig,Michel C. Nussenzweig,Anthony P. West,Pamela J. Bjorkman +15 more
TL;DR: Classifications and structural analyses provide rules for assigning current and future human RBD-targeting antibodies into classes, evaluating avidity effects, suggesting combinations for clinical use, and providing insight into immune responses against SARS-CoV-2.