Showing papers by "Shaofa Sun published in 2016"
TL;DR: In this article, an efficient catalytic method for α-trifluoromethylthiolation of aldehydes has been developed, using an easily accessible reagent and commercially available starting materials.
Abstract: An efficient catalytic method for α-trifluoromethylthiolation of aldehydes has been developed. The reaction occurred by using an easily accessible reagent and commercially available starting materials. The convenient manipulation and broad functional group tolerance allow the potential of this new methodology to be widely applied in organic synthesis as well as in the industrial, pharmaceutical and agrochemical fields.
20 citations
TL;DR: An efficient and one-step synthesis of indolizine-1-carbaldehydes from phenylpropiolaldehyde and pyridinium ylides was developed and afforded functionalized indolIZines with easy operation under mild reaction conditions and with wide substrate scope.
19 citations
TL;DR: In this article, 1,2-oxazol derivatives were prepared by a highly regioselective 1,3-dipolar cycloaddition of nitrile oxides and α,β-acetylenical dehydes in good yields.
14 citations
TL;DR: A plausible mechanism of the cyclization step of the quinazolines class synthesized by the formic acid-catalyzed intramolecular cyclization of 3-(2-aminoalkyl)-2-(phenylamino)quinazolin-4(3H)-ones 1 in high yields is proposed.
Abstract: Bioactive tricyclic quinazolines class of 3,4-dihydro-1H-pyrimido[2,1-b]quinazolin-6(2H)-ones I and 2,3-dihydroimidazo[2,1-b]quinazolin-5(1H)-ones II were synthesized by the formic acid-catalyzed intramolecular cyclization of 3-(2-aminoalkyl)-2-(phenylamino)quinazolin-4(3H)-ones 1 in high yields. A plausible mechanism of the cyclization step is proposed.
8 citations
TL;DR: A novel protocol to synthesize tert- butyl esters from benzyl cyanides and tert-butyl hydroperoxide has been successfully achieved and proceeded smoothly in one pot under the metal-free condition.
Abstract: A novel protocol to synthesize tert-butyl esters from benzyl cyanides and tert-butyl hydroperoxide has been successfully achieved. In the presence of tert-butyl hydroperoxide, Csp3–H bond oxidation, C–CN bond cleavage and C–O bond formation proceeded smoothly in one pot under the metal-free condition.
6 citations
3 citations
TL;DR: In this paper, 1,2-oxazol derivatives were prepared by a highly regioselective 1,3-dipolar cycloaddition of nitrile oxides and α,β-acetylenical dehydes in good yields.
Abstract: 1,2-Oxazol derivatives 3 were prepared by a highly regioselective 1,3-dipolar cycloaddition of nitrile oxides and α,β-acetylenicaldehydes 1 in good yields. Reactive nitrile oxides were generated in situ from stable chloro-oxime reagents 2 and triethyl amine. The cycloaddition reaction showed broad substrate scope and good functional group compatibility.
1 citations
TL;DR: In this article, an efficient catalytic method for α-trifluoromethylthiolation of aldehydes has been developed, using an easily accessible reagent and commercially available starting materials.
Abstract: An efficient catalytic method for α-trifluoromethylthiolation of aldehydes has been developed. The reaction occurred by using an easily accessible reagent and commercially available starting materials. The convenient manipulation and broad functional group tolerance allow the potential of this new methodology to be widely applied in organic synthesis as well as in the industrial, pharmaceutical and agrochemical fields.