Shaolin He

TL;DR: It is demonstrated that microRNA-181b regulates NF-κB-mediated EC activation and vascular inflammation in response to proinflammatory stimuli and that rescue of miR-181B expression could provide a new target for antiinflammatory therapy and critical illness.

TL;DR: In this article, the role of microRNA-181b in endothelial NF-κB signaling and effects on atherosclerosis was examined, and it was shown that miR-481b significantly inhibited atherosclerotic lesion formation, proinflammatory gene expression and the influx of lesional macrophages and CD4+ T cells in the vessel wall.

TL;DR: It is shown that miR‐181b and Card10 are important regulators of thrombin‐induced EC activation and arterial thrombosis, and the relevance of microRNA‐dependent targets in response to ligand‐specific signaling in ECs is highlighted.

TL;DR: IL-37 may be a novel potential therapeutic target in patients with atherosclerotic heart disease through reducing inflammation by promoting the differentiation of the T helper cell anti-inflammatory phenotype, and through increasing plaque stability by decreasing matrix metalloproteinase (MMP)-2/13-mediated degradation of collagen and inhibiting VSMCs apoptosis.

TL;DR: The functional TSLPR was surface-expressed on murine platelets, which suggests an important role for TSLP in linking vascular inflammation and thrombo-occlusive diseases.