R
Rebecca M. Baron
Researcher at Brigham and Women's Hospital
Publications - 154
Citations - 8876
Rebecca M. Baron is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Sepsis. The author has an hindex of 35, co-authored 130 publications receiving 6231 citations. Previous affiliations of Rebecca M. Baron include University of Chicago & Harvard University.
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Journal ArticleDOI
Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function
Torsten Olszak,Dingding An,Sebastian Zeissig,Miguel Pinilla Vera,Julia Richter,Andre Franke,Jonathan N. Glickman,Reiner Siebert,Rebecca M. Baron,Dennis L. Kasper,Richard S. Blumberg +10 more
TL;DR: It is shown that in germ-free (GF) mice, invariant natural killer T (iNKT) cells accumulate in the colonic lamina propria and lung, resulting in increased morbidity in models of IBD and allergic asthma as compared with that of specific pathogen-free mice.
Journal ArticleDOI
SARS-CoV-2 viral load is associated with increased disease severity and mortality.
Jesse Fajnzylber,James Regan,Kendyll Coxen,Heather Corry,Colline Wong,Alexandra Rosenthal,Daniel P Worrall,Francoise Giguel,Alicja Piechocka-Trocha,Caroline Atyeo,Stephanie Fischinger,Andrew T. Chan,Keith T. Flaherty,Kathryn T. Hall,Michael Dougan,Edward T. Ryan,Elizabeth Gillespie,Rida Chishti,Yijia Li,Nikolaus Jilg,Nikolaus Jilg,Dusan Hanidziar,Rebecca M. Baron,Lindsey R. Baden,Athe M. N. Tsibris,Katrina Armstrong,Daniel R. Kuritzkes,Galit Alter,Galit Alter,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Xu G. Yu,Xu G. Yu,Jonathan Z. Li +34 more
TL;DR: It is reported that a higher prevalence of detectable SARS-CoV-2 plasma viral load is associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6.
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Inflammasome-regulated cytokines are critical mediators of acute lung injury.
Tamas Dolinay,Young Sam Kim,Judie A. Howrylak,Gary M. Hunninghake,Chang Hyeok An,Laura E. Fredenburgh,Anthony F. Massaro,Angela J. Rogers,Lee Gazourian,Kiichi Nakahira,Jeffrey A. Haspel,Roberto Landazury,Sabitha Eppanapally,Jason D. Christie,Nuala J. Meyer,Lorraine B. Ware,David C. Christiani,Stefan W. Ryter,Rebecca M. Baron,Augustine M.K. Choi +19 more
TL;DR: In samples from four clinical centers, IL-18 was elevated in the plasma of patients with ARDS and served as a novel biomarker of intensive care unit morbidity and mortality and played critical roles in ARDS development.
Journal ArticleDOI
MicroRNA-181b regulates NF-κB–mediated vascular inflammation
Xinghui Sun,Basak Icli,Akm Khyrul Wara,Nathan Belkin,Shaolin He,Lester Kobzik,Gary M. Hunninghake,Miguel Pinilla Vera,Timothy S. Blackwell,Rebecca M. Baron,Mark W. Feinberg +10 more
TL;DR: It is demonstrated that microRNA-181b regulates NF-κB-mediated EC activation and vascular inflammation in response to proinflammatory stimuli and that rescue of miR-181B expression could provide a new target for antiinflammatory therapy and critical illness.
Journal ArticleDOI
An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis
Raymond J. Langley,Raymond J. Langley,Ephraim L. Tsalik,Ephraim L. Tsalik,Jennifer C. van Velkinburgh,Seth W. Glickman,Seth W. Glickman,Brandon J. Rice,Chunping Wang,Bo Chen,Lawrence Carin,Arturo Suarez,Robert P. Mohney,D. Freeman,Mu Wang,Jinsam You,Jacob Wulff,J. Will Thompson,M. Arthur Moseley,Stephanie Reisinger,Brian T. Edmonds,Brian W. Grinnell,David R. Nelson,Darrell L. Dinwiddie,Darrell L. Dinwiddie,Darrell L. Dinwiddie,Neil A. Miller,Neil A. Miller,Carol J. Saunders,Sarah S. Soden,Angela J. Rogers,Lee Gazourian,Laura E. Fredenburgh,Anthony F. Massaro,Rebecca M. Baron,Augustine M.K. Choi,G. Ralph Corey,Geoffrey S. Ginsburg,Charles B. Cairns,Ronny M. Otero,Vance G. Fowler,Emanuel P. Rivers,Christopher W. Woods,Stephen F. Kingsmore,Stephen F. Kingsmore +44 more
TL;DR: A molecular signature, derived from integrated analysis of clinical data, the metabolome, and the proteome in prospective human studies, improved the prediction of death in patients with sepsis, potentially identifying a subset of patients who merit intensive treatment.