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Shaoyu Zhou
Researcher at University of Minnesota
Publications - 4
Citations - 648
Shaoyu Zhou is an academic researcher from University of Minnesota. The author has contributed to research in topics: Mitochondrial permeability transition pore & Mitochondrion. The author has an hindex of 4, co-authored 4 publications receiving 623 citations.
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Journal Article
Cumulative and Irreversible Cardiac Mitochondrial Dysfunction Induced by Doxorubicin
TL;DR: The data indicate that doxorubicin treatment in vivo causes a dose-dependent and irreversible decrease in mitochondrial calcium loading capacity, which may account for the cumulative and irreversible loss of myocardial function in patients receiving doxorbicin chemotherapy.
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Doxorubicin-induced persistent oxidative stress to cardiac myocytes
TL;DR: The data suggest that the accumulation and persistence of oxidized mtDNA may be due, not to the stability of the adducts, but to some as yet undefined toxic lesion that causes long-lasting stimulation of ROS generation by doxorubicin.
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The effect of peroxisome proliferators on mitochondrial bioenergetics.
Shaoyu Zhou,Kendall B. Wallace +1 more
TL;DR: The results of this investigation demonstrate that although most, but not all, peroxisome proliferators interfere with mitochondrial bioenergetics, the specific biomolecular mechanism differs among the individual compounds.
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Interference with calcium-dependent mitochondrial bioenergetics in cardiac myocytes isolated from doxorubicin-treated rats.
TL;DR: By interfering with mitochondrial calcium regulation, long-term treatment with DOX renders myocytes susceptible to agents that increase cytosolic calcium, presumably by increasing the calcium-dependent disruption of mitochondrial function, leading to depletion of ATP and eventually cell death.