S
Sharon Sfez
Researcher at Tel Aviv University
Publications - 3
Citations - 3321
Sharon Sfez is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Gene & Positional cloning. The author has an hindex of 3, co-authored 3 publications receiving 3255 citations.
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A single ataxia telangiectasia gene with a product similar to pi-3 kinase
Kinneret Savitsky,Anat Bar-Shira,Shlomit Gilad,Galit Rotman,Yael Ziv,Lina Vanagaite,Danilo A. Tagle,Sara Smith,Tamar Uziel,Sharon Sfez,Maya Ashkenazi,Iris Pecker,Moshe Frydman,Reli Harnik,Sankhavaram R. Patanjali,Andrew D. Simmons,Gregory A. Clines,Adam Sartiel,Richard A. Gatti,Luciana Chessa,Ozden Sanal,Martin F. Lavin,Nicolaas G. J. Jaspers,A. Malcolm R. Taylor,Colin F. Arlett,Toru Miki,Sherman M. Weissman,Michael Lovett,Francis S. Collins,Yosef Shiloh +29 more
TL;DR: A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia was identified by positional cloning on chromosome 11q22-23 and encoded a putative protein that is similar to several yeast and mammalian phosphatidylinositol-3' kinases that are involved in mitogenic signal transduction, meiotic recombination, and cell cycle control.
Journal ArticleDOI
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
Kinneret Savitsky,Sharon Sfez,Danilo A. Tagle,Yael Ziv,Adam Sartiel,Francis S. Collins,Yosef Shiloh,Gallt Rotman +7 more
TL;DR: The molecular cloning of a cDNA contig spanning the complete open reading frame of the ATM gene provides useful clues to the function of this protein, and furthers understanding of the pleiotropic nature of the A-T mutations.
Journal ArticleDOI
A Human Gene (DDX10) Encoding a Putative DEAD-Box RNA Helicase at 11q22–q23
Kinneret Savitsky,Yael Ziv,Anat Bar-Shira,Shlomit Gilad,Danilo A. Tagle,Sara Smith,Tamar Uziel,Sharon Sfez,Joseph Nahmias,Adam Sartiel,Roger L. Eddy,Thomas B. Shows,Francis S. Collins,Yosef Shiloh,Galit Rotman +14 more
TL;DR: A human gene encoding a putative RNA helicase, designated DDX10, was identified 400 kb telomeric to the ataxia-telangiectasia gene at chromosome 11q22-q23 and a rare trinucleotide repeat length polymorphism was observed within the coding sequence.