S
Shayn M. Peirce
Researcher at University of Virginia
Publications - 146
Citations - 4881
Shayn M. Peirce is an academic researcher from University of Virginia. The author has contributed to research in topics: Pericyte & Chemistry. The author has an hindex of 34, co-authored 129 publications receiving 4129 citations. Previous affiliations of Shayn M. Peirce include University of Virginia Health System & Georgia Institute of Technology.
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Ischemia-reperfusion injury in chronic pressure ulcer formation: a skin model in the rat.
TL;DR: This model generates reproducible ischemia‐reperfusion skin injury as characterized by tissue necrosis, wound thickness, leukocyte infiltration, transcutaneous oxygen tension, and wound blood flow.
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Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis.
TL;DR: This review presents macrophages as a cellular link that spatially and temporally connects angiogenesis with lymphangiogenesis, in both physiological growth and in pathological adaptations, such as tumorigenesis.
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Multiscale Computational Models of Complex Biological Systems
TL;DR: This review aims to highlight recently published multiscale models of biological systems, using their successes to propose the best practices for future model development and demonstrate that coupling continuous and discrete systems best captures biological information across spatial scales.
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Human Adipose-Derived Stromal Cells Accelerate Diabetic Wound Healing: Impact of Cell Formulation and Delivery
Peter J. Amos,Sahil K. Kapur,Peter C. Stapor,Peter C. Stapor,Hulan Shang,Stefan Bekiranov,Moshe Khurgel,George T. Rodeheaver,Shayn M. Peirce,Adam J. Katz +9 more
TL;DR: After treatment with ASCs that were formulated as multicellular aggregates, diabetic wounds experienced a significant increase in the rate of wound closure compared to wounds treated with an equal number of ASCs delivered in suspension.
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Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury
Claire E. Olingy,Cheryl L. San Emeterio,Molly E. Ogle,Jack R. Krieger,Anthony C. Bruce,David D. Pfau,Brett T. Jordan,Shayn M. Peirce,Edward A. Botchwey +8 more
TL;DR: It is demonstrated that circulating non-classical monocytes are directly recruited to polymer films within skin injuries, where they home to a perivascular niche and generate alternatively activated, wound healing macrophages.