Sheela Hanasoge

TL;DR: It is shown that H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is induced in all phases of the cell cycle and is mediated primarily by the ATR kinase.

TL;DR: It is proposed that this transcription-based stress response involving RPA, ATR, and p53 has evolved as aDNA damage-sensing mechanism to safeguard cells against DNA damage-induced mutagenesis.

TL;DR: These findings suggest that CI-1033 can increase the effectiveness of radiation therapy and the extent of suppression of tyrosine kinase activity by CI- 1033, rather than the amount of activity in untreated cells, seemed to be more closely associated with the efficacy of combination treatment.

TL;DR: It is shown that hCdc14A is differentially expressed in human tissues and in 75 cancer cell lines examined and that it forms a complex with Cdk1/cyclin B during interphase but not during mitosis, implicate that dysregulation of hCDC14A expression may play a role in carcinogenesis.

TL;DR: Thirty-two in 2 Gy daily fractions can be delivered safely when combined with HA chemotherapy and subsequent transarterial chemoembolization, however, although objective responses were observed, this combination was not significantly better than prior approaches.