T
Theodore S. Lawrence
Researcher at University of Michigan
Publications - 588
Citations - 31480
Theodore S. Lawrence is an academic researcher from University of Michigan. The author has contributed to research in topics: Radiation therapy & Cancer. The author has an hindex of 86, co-authored 563 publications receiving 27454 citations. Previous affiliations of Theodore S. Lawrence include Rockefeller University.
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Journal ArticleDOI
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
Weimin Wang,Michael D. Green,Jae Eun Choi,Miguel Gijón,Paul D. Kennedy,Jeffrey K. Johnson,Peng Liao,Xueting Lang,Ilona Kryczek,Amanda Sell,Houjun Xia,Jiajia Zhou,Gaopeng Li,Jing Li,Wei Li,Shuang Wei,Linda Vatan,Hongjuan Zhang,Wojciech Szeliga,Wei Gu,Rebecca Liu,Theodore S. Lawrence,Candice Lamb,Yuri Tanno,Marcin Cieslik,Everett Stone,George Georgiou,Timothy A. Chan,Arul M. Chinnaiyan,Arul M. Chinnaiyan,Weiping Zou +30 more
TL;DR: Investigation of human transcriptomes before and during nivolumab therapy revealed that clinical benefits correlate with reduced expression of SLC3A2 and increased IFNγ and CD8 and targeting this pathway in combination with checkpoint blockade is a potential therapeutic approach.
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Analysis of radiation-induced liver disease using the Lyman NTCP model.
Laura A. Dawson,Daniel P. Normolle,James M. Balter,Cornelius J. McGinn,Theodore S. Lawrence,Randall K. Ten Haken +5 more
TL;DR: It is demonstrated that the liver exhibits a large volume effect for RILD, suggesting that the mean liver dose may be useful in ranking radiation plans.
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MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells.
Qing Ji,Xinbao Hao,Xinbao Hao,Min Zhang,Wenhua Tang,Meng Yang,Ling-Ling Li,Debing Xiang,Jeffrey T. DeSano,Guido T. Bommer,Daiming Fan,Eric R. Fearon,Theodore S. Lawrence,Liang Xu +13 more
TL;DR: The results demonstrate that miR-34 may restore, at least in part, the tumor suppressing function of the p53 in p53-deficient human pancreatic cancer cells.
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Functional diffusion map: A noninvasive MRI biomarker for early stratification of clinical brain tumor response
Bradford A. Moffat,Thomas L. Chenevert,Theodore S. Lawrence,Charles R. Meyer,Timothy D. Johnson,Qian Dong,Christina Tsien,Suresh K. Mukherji,Douglas J. Quint,Stephen S. Gebarski,Patricia L. Robertson,Larry Junck,Alnawaz Rehemtulla,Brian D. Ross +13 more
TL;DR: Overall, fDM analysis provided an early biomarker for predicting treatment response in brain tumor patients, revealing that early changes in tumor diffusion values could be used as a prognostic indicator of subsequent volumetric tumor response.
Journal ArticleDOI
Hepatic toxicity resulting from cancer treatment
Theodore S. Lawrence,John M. Robertson,Mitchell S. Anscher,Randy L. Jirtle,William D. Ensminger,Luis F. Fajardo +5 more
TL;DR: The characteristics of RILD permit the development of a grading system modeled after the NCI Acute Common Toxicity Criteria, which incorporates standard criteria of hepatic dysfunction, and three dimensional treatment planning offers the potential to determine the radiation dose and volume dependence of RLD.