S
Sheelagh Frame
Researcher at University of Dundee
Publications - 48
Citations - 5450
Sheelagh Frame is an academic researcher from University of Dundee. The author has contributed to research in topics: Seliciclib & Cyclin-dependent kinase. The author has an hindex of 17, co-authored 48 publications receiving 5121 citations.
Papers
More filters
Journal ArticleDOI
The renaissance of GSK3.
Philip Cohen,Sheelagh Frame +1 more
TL;DR: Glycogen synthase kinase 3 was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of cell functions.
Journal ArticleDOI
GSK3 takes centre stage more than 20 years after its discovery.
Sheelagh Frame,Philip Cohen +1 more
TL;DR: These latest findings have generated an enormous amount of interest in the development of drugs that inhibit GSK3 and which may have therapeutic potential for the treatment of diabetes, stroke and Alzheimer's disease.
Journal ArticleDOI
A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation
TL;DR: It is demonstrated that the insulin-induced inhibition of GSK3 and its unique substrate specificity are explained by the existence of a phosphate binding site in which Arg- 96 is critical, and mutation of Arg-96 abolishes the phosphorylation of "primed" glycogen synthase as well as inhibition by PKB-mediated phosphorylated of Ser-9.
Journal ArticleDOI
Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event.
TL;DR: The results indicate that the tyrosine phosphorylation of GSK3 is an intramolecular autophosphorylation event in the cells that are studied and that this modification enhances the stability of the enzyme.
Journal ArticleDOI
Seliciclib (CYC202, R-Roscovitine) Induces Cell Death in Multiple Myeloma Cells by Inhibition of RNA Polymerase II–Dependent Transcription and Down-regulation of Mcl-1
David E. MacCallum,Jean Melville,Sheelagh Frame,Kathryn Watt,Sian Anderson,Athos Gianella-Borradori,David P. Lane,Simon Green +7 more
TL;DR: The results suggest that seliciclib causes myeloma cell death by disrupting the balance between cell survival and apoptosis through the inhibition of transcription and down-regulation of Mcl-1.