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Sheng-Chung Lee

Researcher at National Taiwan University

Publications -  61
Citations -  2776

Sheng-Chung Lee is an academic researcher from National Taiwan University. The author has contributed to research in topics: Regulation of gene expression & Transcription factor. The author has an hindex of 31, co-authored 61 publications receiving 2628 citations. Previous affiliations of Sheng-Chung Lee include Academia Sinica.

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Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication

Bertrand Chin-Ming Tan, +4 more
- 06 Sep 2006 - 
TL;DR: It is shown that the heterodimeric transcriptional elongation factor FACT (facilitates chromatin transcription) is functionally linked to DNA synthesis and supported a model in which the concerted action of helicase and chromatin‐modifying activities promotes chromosome replication.
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Clonal Origin of Recurrent Hepatocellular Carcinomas

Pei-Jer Chen, +9 more
- 01 Feb 1989 - 
TL;DR: It is concluded that recurrent hepatocellular carcinomas originate from the first tumor in some cases but represent de novo neoplasms in others.
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FACT facilitates chromatin transcription by RNA polymerases I and III

Joanna Birch, +9 more
- 08 Apr 2009 - 
TL;DR: These findings indicate that FACT has physiological functions in chromatin transcription by all three nuclear RNA Pols, and imply that local chromatin dynamics influence transcription of the active rRNA genes by Pol I and of Pol III‐transcribed genes.
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The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 Phosphorylation

David E. White, +8 more
- 01 Mar 2012 - 
TL;DR: It is shown that HP1α and unmodified KAP1 are enriched in endogenous heterochromatic loci and at a silent transgene prior to damage and following damage, γH2AX and pKAP1-s824 rapidly increase and persist at these loci.
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Purification and characterization of nucleolin and its identification as a transcription repressor.

Tzung-Horng Yang, +7 more
- 01 Sep 1994 - 
TL;DR: Biochemical and functional studies further established that nucleolin is a transcription repressor for regulation of AGP and possibly other acute-phase response genes, and may also function as a transcriptional repressor.