Showing papers in "Gastroenterology in 1989"

TL;DR: It is concluded that Caco-2 cells grown on collagen-coated polycarbonate membranes should represent a valuable transport model system for the small intestinal epithelium.

TL;DR: The successful use of orthotopic liver transplants in fulminant hepatic failure has created a need for early prognostic indicators to select the patients most likely to benefit at a time when liver transplantation is still feasible.

TL;DR: A simple and reproducible rat model of chronic colonic inflammation by the intraluminal instillation of a solution containing a "barrier breaker" and a hapten to study the pathophysiology of colonic inflammatory disease in a specifically controlled fashion and to evaluate new treatments potentially applicable to inflammatory bowel disease in humans.

TL;DR: The Inflammatory Bowel Disease Questionnaire shows promise as a measure of health status for clinical trials in IBD, and responsiveness appeared greater in patients with ulcerative colitis than in those with Crohn's disease.

TL;DR: The results of this study support the need for a long-term clinical, endoscopic, and histologic follow-up program in patients with Barrett's esophagus with an incidence of carcinoma of 1 in 52 patient-years, a 125-fold increase compared with the general Dutch population.

TL;DR: The data is reviewed and mechanisms that implicate C. pylori as an important factor in the pathogenesis of peptic ulcer disease are proposed and the therapeutic implications are considered.

TL;DR: Les auteurs rapportent les modifications immunopathologiques observees au cours de la maladie cœliaque et des colites inflammatoires qui pourraient expliquer the pathogenese de ces maladies.

TL;DR: It is concluded that S. boulardii reduces the incidence of antibiotic-associated diarrhea in hospitalized patients and there were no discernable adverse effects of yeast administration.

TL;DR: It is demonstrated that inhibition of leukotriene synthesis results in a marked acceleration of the healing of Colonic ulcers and resolution of colonic inflammation in this animal model of chronic colitis, consistent with the hypothesis thatLeukotrienes play an important role in the pathogenesis of intestinal inflammation.

TL;DR: Mast cell/nerve associations have been recorded in several publications; however, the human gastrointestinal tract has received little attention, and mucosal samples from small bowel, appendix, and large bowel were studied to provide a microanatomic basis for potential communication between nerves and mast cells in the humanintestinal mucosa.

TL;DR: Compared ultrasound images with the corresponding histologic sections of 81 specimens of resected and postmortem, normal and diseased gastrointestinal tissue, it is shown that normal findings on ultrasound images of neoplastic and inflammatory diseases correspond to histologic tissue structure.

TL;DR: It is concluded that transsphincteric transport of increasing swallow bolus volumes is accomplished by modulating sphincter diameter, opening interval, and flow rate (reflected by bolus head velocity), rather than simply a consequence of cricopharyngeal relaxation.

TL;DR: It is estimated that the syndrome of NSAID-associated gastropathy can be estimated to account for at least 2600 deaths and 20,000 hospitalizations each year in patients with rheumatoid arthritis alone.

TL;DR: A specific and sensitive enzyme-linked immunosorbent assay (ELISA) that detects serum immunoglobulin G antibodies directed against high molecular weight cell-associated proteins (HM-CAP) of C. pylori that is less expensive and easier to perform.

TL;DR: In studies with erythrocyte membranes, changes in electron spin resonance revealed that ursodeoxycholic acid was less toxic than chenode oxygencholic or deoxycholics acid, and coaddition of ursodesxycholic Acid prevented their toxic effect.

TL;DR: Lactulose, in particular, detects permeability changes in patients with intestinal inflammation, and polyethylene glycol 400 is able to detect permeable changes in the health relatives of the authors' patients.

TL;DR: The results of this study permit the following model: short-chain fatty acid stimulation of active Na and Cl absorption involves uptake of the nonionized form of butyrate and the coupling of Na-H and Cl-butyrate exchanges.

TL;DR: Pending a larger case-control study, folate supplementation during sulfasalazine administration is recommended to possibly prevent the complication of dysplasia or cancer in ulcerative colitis.

TL;DR: Endosonography was superior to computed tomography in the evaluation of the depth of tumor infiltration, especially in the early stages and in nonresectable carcinoma and in regional lymph node metastases.

TL;DR: The hypothesis that sex steroid hormones have variable inhibitory effects on gastric emptying of a mixed meal and this should be considered when studying gastric emptied in disorders that occur predominantly in premenopausal women is supported.

TL;DR: The combined procedure improves the ability of endoscopy to offer nonsurgical therapy to poor risk patients with both malignant and benign biliary disease but is associated with significant morbidity and disease-related mortality.

TL;DR: The mortality experienced by a cohort of 653 patients with celiac disease in Edinburgh and the Lothian region has been analyzed and there was no deficit in deaths from ischemic heart disease or stroke and the mortality rate in those diagnosed in childhood as having Celiac disease was similar to the general population.

TL;DR: In this TNB/ethanol model of gut inflammation, myeloperoxidase activity and interleukin-1 are reliable and sensitive indicators of colonic inflammation, and that thromboxane B2 is not involved in the acute lesions, whereas leukotriene B4 appears in the chronic active inflammatory response.

TL;DR: It is concluded that acid injury of the upper gastrointestinal tract is a very serious condition that affects the esophagus and stomach equally and results in high morbidity and mortality.

TL;DR: In this paper, meta-analytic methods were applied to review clinical trials published in English that have assessed the efficacy of parenteral nutrition for cirrhotic patients with acute hepatic encephalopathy.

TL;DR: Of 97 patients referred with suspected non-A, non-B hepatitis, 3 were found to have antibody to the human immunodeficiency virus and developed symptomatic cirrhosis within 3 yr of onset of hepatitis.

TL;DR: A synthetic "mixed" triglyceride (1,3-distearoyl,2[13C]octanoyl glycerol), having a medium-chain fatty acid in the 2 position, was evaluated as a substrate for an exocrine pancreatic function test by comparing the 13CO2 breath excretion with the lipase output in the duodenum.

TL;DR: The presence of the concentration gradient suggests that a mechanism for the secretion of vitamin C into the stomach exists, and those patients who by the Correa model are at greatest risk for gastric cancer have the lowest gastric levels of ascorbic acid.

TL;DR: Findings indicate that the bacterial ecology of ileal pouches has an important influence on the morphology of their mucosal lining.

TL;DR: The results indicate that a highly purified suspension of viable, morphologically intact, and polar IBDECs can be prepared from normal rat liver using a novel approach that separates liver cells on the basis of size, density, and specific membrane components.