Sheng-Xiang Lin

TL;DR: This work achieves a storage efficiency of 92.0 (1.5)% for a coherent optical memory based on the electromagnetically induced transparency scheme in optically dense cold atomic media and gets a useful time-bandwidth product of 1200, considering only storage where the retrieval efficiency remains above 50%.

TL;DR: The rationale for inhibiting 17beta-HSD1 in breast cancer therapy to eliminate estrogen activation via the sulfatase pathway while avoiding the deprivation of DHT is strongly supported.

TL;DR: The binding poses of three viral RdRp inhibitors (Galidesivir, Favipiravir, and Penciclovir), which were recently reported to have clinical significance for SARS-CoV-2, are demonstrated and the network of interactions established by these drug molecules affirms their efficacy to inhibit viral RNA replication and provides an insight into their structure-based rational optimization for SERS inhibition.

TL;DR: The design of a bisubstrate inhibitor of 17beta-HSD1, the estradiol/adenosine hybrid EM-1745, is reviewed and strategies for future designs of inhibitors are proposed.

TL;DR: The synthesis of 5′-O-[3-(3′,17′β-dihydroxy-1′, 3′,5′(10′)-estratrien-16′α-yl)propanoyl]adenosine is reported focusing on the crucial last steps: the coupling of adenosine residue to estradiol side chain by an ester link and the appropriate final cleavage of three protecting groups.