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Shengnan Wei
Researcher at Jilin University
Publications - 11
Citations - 576
Shengnan Wei is an academic researcher from Jilin University. The author has contributed to research in topics: AMPK & Gluconeogenesis. The author has an hindex of 10, co-authored 11 publications receiving 431 citations.
Papers
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Journal ArticleDOI
Adipocyte-Derived Exosomal MiR-27a Induces Insulin Resistance in Skeletal Muscle Through Repression of PPARγ.
Yang Yu,Hongwei Du,Shengnan Wei,Linjing Feng,Junnan Li,Fan Yao,Ming Zhang,Grant M. Hatch,Li Chen +8 more
TL;DR: It is indicated that adipose tissue-derived miR-27a may play a key role in the development of obesity-triggered insulin resistance in skeletal muscle.
Journal ArticleDOI
Berberine improves insulin resistance in cardiomyocytes via activation of 5'-adenosine monophosphate-activated protein kinase.
Wenguang Chang,Ming Zhang,Jing Li,Zhaojie Meng,Shengnan Wei,Hongwei Du,Li Chen,Grant M. Hatch +7 more
TL;DR: Berberine significantly increased AMPK activity, but had little effect on the activity of protein kinase B (AKT) in insulin resistant H9c2 cells, suggesting that berberine improves insulin resistance in H 9c2 cardiomyocytes at least in part via stimulation of AM PK activity.
Journal ArticleDOI
Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway
Shengnan Wei,Ming Zhang,Ming Zhang,Yang Yu,Xiaoxin Lan,Fan Yao,Xin Yan,Li Chen,Grant M. Hatch +8 more
TL;DR: Examination of the mechanism of how BBR attenuates hepatic gluconeogenesis and the lipid metabolism alterations observed in type 2 diabetic mice and in palmitate-incubated HepG2 cells indicates that miR122 is a critical regulator in the downstream pathway of HNF-4α in the regulation of hepatic glucoseogenesis and lipid metabolism in HepG 2 cells.
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Berberine Attenuates Ischemia-Reperfusion Injury Via Regulation of Adenosine-5′-monophosphate Kinase Activity in Both Non-ischemic and Ischemic Areas of the Rat Heart
Wenguang Chang,Ming Zhang,Jing Li,Zhaojie Meng,Dong Xiao,Shengnan Wei,Li Chen,Chun-yan Wang,Grant M. Hatch +8 more
TL;DR: It is suggested that berberine may exert its cardioprotective effect on ischemia-reperfusion injury via regulation of AMPK activity in both non-ischemic areas and risk areas of the heart.
Journal ArticleDOI
Berberine protects against palmitate-induced endothelial dysfunction: involvements of upregulation of AMPK and eNOS and downregulation of NOX4.
Ming Zhang,Chun-Mei Wang,Jing Li,Zhaojie Meng,Shengnan Wei,Ji Li,Richard Bucala,Yu-Lin Li,Li Chen +8 more
TL;DR: In this paper, the authors investigated the effect of berberine on palmitate-induced endothelial dysfunction in human umbilical vein endothelial cells (HUVECs).