Showing papers by "Sher Bahadar Khan published in 2007"

Leufolins A and B, Potent Butyrylcholinesterase-inhibiting Flavonoid Glucosides from Leucas urticifolia

Abstract: New flavonoidal glucosides leufolins A ( 1 ) and B ( 2 ), have been isolated from the ethyl acetate soluble fraction of the whole plants of Leucas urticifolia . Their structures were elucidated on the basis of extensive analysis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Both of these compounds exhiited significant inhibitory potential against the enzyme butyrylcholinesterase. Keywords: Leucas urticifolia, Lamiaceae, Leufolin A, Leufolin B, Butyrylcholinesterase, Inhibitory activity __________________________________________________________________________________ Introduction The genus Leucas , belonging to the family Lamiaceae, comprises about 100 species. In the Indo-Pakistani subcontinent, the genus is represented by 35 species which are mostly herbs or undershrubs found in temperate or hilly regions [1]. L. urticifolia is an annual herb which is commonly found in Karachi and other parts of Sind province of Pakistan. It is astringent, stimulant, haemostatic,

Aminolyses of Y-substituted Phenyl 2-Furoates and Cinnamates: Effect of Nonleaving Group Substituent on Reactivity and Mechanism

Abstract: ) with strongly basic piperidine and weaklybasic morpholine. We have fou nd that the Bronsted-type plotis curved for the reactions with piperidine but is linear forthose with morpholine. We report the effect of modificationof the nonleaving moiety from cinnamoyl to 2-furoyl onreactivity as well as on reaction mechanism.