S
Sherry L. Morissette
Researcher at Boehringer Ingelheim
Publications - 19
Citations - 2527
Sherry L. Morissette is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Crystal structure & COPD. The author has an hindex of 13, co-authored 19 publications receiving 2418 citations. Previous affiliations of Sherry L. Morissette include Chartered Institute of Management Accountants & University of South Florida.
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Journal ArticleDOI
High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids
Sherry L. Morissette,Orn Almarsson,Matthew Peterson,Julius F. Remenar,Michael Read,Anthony V. Lemmo,Steve Ellis,Michael J. Cima,Colin R. Gardner +8 more
TL;DR: The impact of form diversity encompasses issues of stability and bioavailability, as well as development considerations such as process definition, formulation design, patent protection and regulatory control.
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Crystal engineering of novel cocrystals of a triazole drug with 1,4-dicarboxylic acids.
Julius F. Remenar,Sherry L. Morissette,Matthew Peterson,Brian Moulton,J. Michael Macphee,Hector Guzman,Orn Almarsson +6 more
TL;DR: The results suggest that cocrystals of drug molecules have the possibility of achieving the higher oral bioavailability common for amorphous forms of water-insoluble drugs while maintaining the long-term chemical and physical stability that crystal forms provide.
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Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high-throughput crystallization.
TL;DR: Dunitz et al. as mentioned in this paper carried out high-throughput crystallization experiments to comprehensively explore ritonavir form diversity and found a total of five forms: both known forms and three previously unknown forms.
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Iterative high-throughput polymorphism studies on acetaminophen and an experimentally derived structure for form III.
Matthew Peterson,Sherry L. Morissette,Chris McNulty,Andrew M. Goldsweig,Paul E. Shaw,Martin LeQuesne,Julie Monagle,Nicolas Encina,Joseph Marchionna,Alasdair Johnson,Javier Gonzalez-Zugasti,Anthony V. Lemmo,Stephen J. Ellis,Michael J. Cima,Orn Almarsson +14 more
TL;DR: Three crystal forms of acetaminophen were prepared and characterized using a newly developed high-throughput crystallization platform, CrystalMax, and one structure suggested has a bilayer motif, held together by O-H...O(H) hydrogen bonds, and helps explain the difficulty associated with preparing this form from solution.
Journal ArticleDOI
High-Throughput Surveys of Crystal Form Diversity of Highly Polymorphic Pharmaceutical Compounds
Orn Almarsson,Magali B. Hickey,Matthew Peterson,Sherry L. Morissette,Stephen Soukasene,Chris McNulty,Mark Tawa,J. Michael Macphee,Julius F. Remenar +8 more
TL;DR: In this article, a survey of crystal form diversity of two test compounds, 1 (an experimental angiotensin II antagonist) and 2 (sertraline HCl, the active drug in Zoloft), has been performed with high-throughput (HT) crystallization.