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Shi-Qi An
Researcher at University of Southampton
Publications - 39
Citations - 1066
Shi-Qi An is an academic researcher from University of Southampton. The author has contributed to research in topics: Virulence & Xanthomonas campestris. The author has an hindex of 16, co-authored 39 publications receiving 796 citations. Previous affiliations of Shi-Qi An include University College Cork & University of Dundee.
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Journal ArticleDOI
The DSF Family of Cell–Cell Signals: An Expanding Class of Bacterial Virulence Regulators
TL;DR: The role of DSF family signals in interspecies signaling that modulates the behavior of other microorganisms is addressed and a number of recently reported approaches for the control of bacterial virulence through the modulation ofDSF signaling are considered.
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Mechanistic insights into host adaptation, virulence and epidemiology of the phytopathogen Xanthomonas.
Shi-Qi An,Neha Potnis,Max Dow,Frank-Jörg Vorhölter,Yong-Qiang He,Anke Becker,Doron Teper,Yi Li,Nian Wang,Leonidas Bleris,Ji-Liang Tang +10 more
TL;DR: The current knowledge on the infection strategies and regulatory networks controlling virulence and adaptation mechanisms from Xanthomonas species are summarized and the novel opportunities that this body of work has provided for disease control and plant health are discussed.
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Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre.
Dom Bellini,Delphine L. Caly,Yvonne McCarthy,Mario Bumann,Shi-Qi An,J. Maxwell Dow,Robert P. Ryan,Martin A. Walsh +7 more
TL;DR: This structure completes the picture of all domains involved in c‐di‐GMP metabolism and reveals that the HD‐GYP family splits into two distinct subgroups containing bi‐ and trinuclear metal centres.
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Microbiota and metabolite profiling reveal specific alterations in bacterial community structure and environment in the cystic fibrosis airway during exacerbation.
Kate B. Twomey,Mark Alston,Shi-Qi An,Oisin J. O'Connell,Yvonne McCarthy,David Swarbreck,Melanie Febrer,Melanie Febrer,J. Maxwell Dow,Barry J. Plant,Robert P. Ryan,Robert P. Ryan +11 more
TL;DR: This study has identified organisms whose occurrence within the CF microbiome has been hitherto unreported and has revealed potential metabolic biomarkers for exacerbation.
Journal ArticleDOI
Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence
Shi-Qi An,Delphine L. Caly,Yvonne McCarthy,Sarah Murdoch,Joseph Ward,Melanie Febrer,J. Maxwell Dow,Robert P. Ryan +7 more
TL;DR: Genetic and functional analysis of YajQ family members from the human pathogens Pseudomonas aeruginosa and Stenotrophomonas maltophilia showed that they also specifically bound cyclic di-GMP and contributed to virulence in model systems.