S
Shigeki Miyamoto
Researcher at University of Tokyo
Publications - 15
Citations - 1264
Shigeki Miyamoto is an academic researcher from University of Tokyo. The author has contributed to research in topics: Cardiac muscle & Ryanodine receptor. The author has an hindex of 8, co-authored 15 publications receiving 1242 citations.
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Journal Article
Calcium Movements, Distribution, and Functions in Smooth Muscle
Hideaki Karaki,Hiroshi Ozaki,Masatoshi Hori,Minori Mitsui-Saito,Ken-ichi Amano,Ken-ichi Harada,Shigeki Miyamoto,Hiroshi Nakazawa,Kyung-Jong Won,Koichi Sato +9 more
TL;DR: Contraction of smooth muscle is regulated by the cytosolic Ca2+ level ([Ca2+]i)b, and the sensitivity of the contractile elements in response to changes in the environment surrounding the cell.
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Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats
TL;DR: Increased airway smooth muscle contractility observed in asthmatics may be related to augmented agonist‐induced, Rho‐mediated Ca2+ sensitization of myofilaments.
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Upregulation of iNOS by COX-2 in muscularis resident macrophage of rat intestine stimulated with LPS.
Masatoshi Hori,Muneto Kita,Shigeko Torihashi,Shigeki Miyamoto,Won Kj,Koichi Sato,Hiroshi Ozaki,Hideaki Karaki +7 more
TL;DR: Findings show that LPS increases iNOS expression and stimulates NO production in muscularis resident macrophages to inhibit smooth muscle contraction.
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Xestospongin C, a selective and membrane-permeable inhibitor of IP3 receptor, attenuates the positive inotropic effect of α-adrenergic stimulation in guinea-pig papillary muscle
Shigeki Miyamoto,Masanori Izumi,Masatoshi Hori,Motomasa Kobayashi,Hiroshi Ozaki,Hideaki Karaki +5 more
TL;DR: The results suggest that the IP3‐mediated increase in Ca2+ release is involved in the positive inotropic effects of α‐adrenergic stimulation in the guinea‐pig cardiac muscle.
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Different pathways of calcium sensitization activated by receptor agonists and phorbol esters in vascular smooth muscle
TL;DR: The results suggest that there are two pathways for Ca2+ sensitization in rat aorta; a protein kinase C‐dependent pathway which is activated by phorbol esters, and aprotein kinases C‐independent pathway which are activated by receptor agonists.